1. Gene
  2. ARL8B - ADP ribosylation factor like GTPase 8B Gene

ARL8B - ADP ribosylation factor like GTPase 8B Gene

Homo sapiens

Also known as Gie1; ARL10C

Gene ID: 55207 | Gene type: protein coding

About ARL8B

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:5,122,292-5,180,911 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues.

Summary

Enables guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; lysosomal transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Colocalizes with lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL8B Products(1)

mRNA Protein Name
NM_018184.3 NP_060654.1 ADP-ribosylation factor-like protein 8B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein activity IDA
IDA: Inferred from direct assay
16537643 GOA
enables GDP binding IDA
IDA: Inferred from direct assay
15331635 GOA
enables GDP binding IMP
IMP: Inferred from mutant phenotype
16650381 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
15331635 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
16650381 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
16537643 GOA
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
15331635 GOA
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
15331635 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21802320 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antigen processing and presentation following phagocytosis IMP
IMP: Inferred from mutant phenotype
21802320 GOA
involved in autophagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
28325809 GOA
involved in calcium ion regulated lysosome exocytosis IMP
IMP: Inferred from mutant phenotype
29592961 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
14871887 GOA
involved in early endosome to Golgi transport IDA
IDA: Inferred from direct assay
36282215 GOA
involved in endosome to lysosome transport of low-density lipoprotein particle IMP
IMP: Inferred from mutant phenotype
21802320 GOA
involved in late endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
28325809 GOA
involved in lysosome localization IDA
IDA: Inferred from direct assay
16537643 GOA
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
16650381 GOA
involved in natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
24088571 GOA
involved in phagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
21802320 GOA
involved in plasma membrane repair IMP
IMP: Inferred from mutant phenotype
29592961 GOA
involved in protein localization to early endosome IDA
IDA: Inferred from direct assay
36282215 GOA
involved in viral exocytosis IMP
IMP: Inferred from mutant phenotype
33157038 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytolytic granule membrane IDA
IDA: Inferred from direct assay
24088571 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15331635 GOA
is active in early endosome membrane IDA
IDA: Inferred from direct assay
36282215 GOA
colocalizes with lysosomal membrane IDA
IDA: Inferred from direct assay
25898167 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
27808481 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
22172677 GOA
located in lysosome IDA
IDA: Inferred from direct assay
21802320 GOA
located in lysosome IMP
IMP: Inferred from mutant phenotype
16650381 GOA
located in midbody IDA
IDA: Inferred from direct assay
15331635 GOA
located in spindle midzone IDA
IDA: Inferred from direct assay
15331635 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL8B Protein Structure

Arf

Arf: ADP-ribosylation factor family (11 - 179)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 8B

ADP-ribosylation factor-like 10C

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS

Sedaghatian Chondrodysplasia

Spondylometaphyseal Dysplasia Sedaghatian Type

Congenital Lethal Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia, Congenital Lethal

Lethal Metaphyseal Dysplasia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARL8B VGNC VGNC:84238
Rattus norvegicus ARL8B RGD RGD:1562830
Mus musculus ARL8B MGD MGI:1914416
Canis familiaris ARL8B VGNC VGNC:38122
Felis catus ARL8B VGNC VGNC:59930
Bos taurus ARL8B VGNC VGNC:26154