2. Gene
  3. YOD1 - YOD1 deubiquitinase Gene

YOD1 - YOD1 deubiquitinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DUBA8; OTUD2; PRO0907

Gene ID: 55432 | Gene type: protein coding

About YOD1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,043,849-207,053,116 (from NCBI)

This gene has 2 transcripts (splice variants) and 201 orthologues. Broad expression in bone marrow (RPKM 24.5), esophagus (RPKM 15.7) and 23 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

YOD1 Products(2)

mRNA Protein Name
NM_001276320.2 NP_001263249.1 ubiquitin thioesterase OTU1 isoform 2
NM_018566.4 NP_061036.3 ubiquitin thioesterase OTU1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
21376232 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
19818707 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19818707 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24068323 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
19818707 GOA
involved in endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
19818707 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
27753622 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
24068323 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K11-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
24068323 GOA
involved in protein K27-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K29-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K33-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
19818707 GOA
involved in protein K48-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
24068323 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
19818707 GOA
involved in protein K63-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
24068323 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27753622 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YOD1 Protein Structure

OTU

OTU: OTU-like cysteine protease (155 - 254)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase OTU1

DUBA-8

YOD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
YOD1 Q5VVQ6 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 ZFP57 Homo sapiens Q9NU63-3
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 ZFP57 Homo sapiens Q9NU63-3
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 ZFP57 Homo sapiens Q9NU63-3
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 RFC2 Homo sapiens P35250-2
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 RFC2 Homo sapiens P35250-2
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 UBXN6 Homo sapiens Q9BZV1
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 UBXN6 Homo sapiens Q9BZV1
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 UBXN6 Homo sapiens Q9BZV1
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 SPART Homo sapiens Q8N0X7
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 SPART Homo sapiens Q8N0X7
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 SPART Homo sapiens Q8N0X7
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 NGRN Homo sapiens Q9NPE2
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 NGRN Homo sapiens Q9NPE2
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 NGRN Homo sapiens Q9NPE2
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 VCP Homo sapiens P55072
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 PLEKHB2 Homo sapiens Q96CS7
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 PSMA7 Homo sapiens O14818
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 PSMA7 Homo sapiens O14818
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 TBX22 Homo sapiens Q9Y458
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 TBX22 Homo sapiens Q9Y458
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 TBX22 Homo sapiens Q9Y458
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
YOD1 Q5VVQ6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 PLSCR4 Homo sapiens Q9NRQ2
Y2H Array
32296183
Intra
YOD1 Q5VVQ6 PLSCR4 Homo sapiens Q9NRQ2
Y2H Prey Pooling
32296183
Intra
YOD1 Q5VVQ6 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15930 YOD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YOD1 MGD MGI:2442596
Canis familiaris YOD1 VGNC VGNC:48496
Rattus norvegicus YOD1 RGD RGD:1359726
Macaca mulatta YOD1 VGNC VGNC:79471
Bos taurus YOD1 VGNC VGNC:37033
Others YOD1 NCBI