2. Gene
  3. PLA2G10 - phospholipase A2 group X Gene

PLA2G10 - phospholipase A2 group X Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPLA2; GXPLA2; GXSPLA2; sPLA2-X

Gene ID: 8399 | Gene type: protein coding

About PLA2G10

Cytogenetic location: 16p13.12-p13.11 Genomic coordinates (GRCh38): 16:14,672,548-14,701,850 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 225 orthologues and 8 paralogues. Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues.

Summary

This gene encodes a member of the Phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature Enzyme. This calcium-dependent Enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this Enzyme catalyzes the release of arachidonic acid from cell membrane Phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast Cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

PLA2G10 Products(1)

mRNA Protein Name
NM_003561.3 NP_003552.1 group 10 secretory phospholipase A2 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
IDA: Inferred from direct assay
16962371 GOA
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
12021277 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
15927955 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
16146426 GOA
involved in low-density lipoprotein particle remodeling IDA
IDA: Inferred from direct assay
12021277 GOA
acts upstream of or within lysophospholipid transport IDA
IDA: Inferred from direct assay
15927955 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20844270 GOA
involved in phosphatidic acid metabolic process IDA
IDA: Inferred from direct assay
12359733 GOA
involved in phosphatidylcholine catabolic process IDA
IDA: Inferred from direct assay
12021277 GOA
involved in phosphatidylcholine metabolic process IDA
IDA: Inferred from direct assay
12359733 GOA
involved in phosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
12359733 GOA
involved in phosphatidylglycerol metabolic process IDA
IDA: Inferred from direct assay
12359733 GOA
involved in phosphatidylserine metabolic process IDA
IDA: Inferred from direct assay
12359733 GOA
involved in platelet activating factor catabolic process IDA
IDA: Inferred from direct assay
16962371 GOA
involved in positive regulation of lipid storage IMP
IMP: Inferred from mutant phenotype
18511424 GOA
involved in positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
18511424 GOA
involved in positive regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
18511424 GOA
involved in regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
18511424 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
21805676 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G10 Protein Structure

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (55 - 151)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

group 10 secretory phospholipase A2

group X secretory phospholipase A2

PLA2G10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLA2G10 O15496 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE2A Homo sapiens Q5TA79
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra
PLA2G10 O15496 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
PLA2G10 O15496 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
PLA2G10 O15496 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
PLA2G10 O15496 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE2B Homo sapiens O14633
MAPPIT
32296183
Intra
PLA2G10 O15496 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra
PLA2G10 O15496 LCE1A Homo sapiens Q5T7P2
Y2H Array
32296183
Intra
PLA2G10 O15496 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra
PLA2G10 O15496 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
PLA2G10 O15496 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
PLA2G10 O15496 NOXA1 Homo sapiens Q86UR1-2
Validated Y2H
32296183
Intra
PLA2G10 O15496 POU4F3 Homo sapiens Q15319
Validated Y2H
32296183
Intra
PLA2G10 O15496 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra
PLA2G10 O15496 GATA5 Homo sapiens Q9BWX5
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
PLA2G10 O15496 LCE1C Homo sapiens Q5T751
Validated Y2H
32296183
Intra
PLA2G10 O15496 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
PLA2G10 O15496 HOXC8 Homo sapiens P31273
Validated Y2H
32296183
Intra
PLA2G10 O15496 FOXH1 Homo sapiens O75593
Validated Y2H
32296183
Intra
PLA2G10 O15496 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
Intra
PLA2G10 O15496 TBX6 Homo sapiens O95947
Validated Y2H
32296183
Intra
PLA2G10 O15496 HR Homo sapiens O43593
Validated Y2H
32296183
Intra
PLA2G10 O15496 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra
PLA2G10 O15496 MAL Homo sapiens P21145
Validated Y2H
32296183
Intra
PLA2G10 O15496 TLX3 Homo sapiens O43711
Validated Y2H
32296183
Intra
PLA2G10 O15496 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
PLA2G10 O15496 ROR2 Homo sapiens Q01974
Validated Y2H
32296183
Intra
PLA2G10 O15496 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
PLA2G10 O15496 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
PLA2G10 O15496 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
PLA2G10 O15496 AGXT Homo sapiens P21549
Validated Y2H
32296183
Intra
PLA2G10 O15496 OTX1 Homo sapiens P32242
Validated Y2H
32296183
Intra
PLA2G10 O15496 NTAQ1 Homo sapiens Q96HA8
Anti Tag CoIP
33961781
Intra
PLA2G10 O15496 NTAQ1 Homo sapiens Q96HA8
Anti Tag CoIP
28514442
Intra
PLA2G10 O15496 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
PLA2G10 O15496 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
PLA2G10 O15496 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
PLA2G10 O15496 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
PLA2G10 O15496 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra
PLA2G10 O15496 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra
PLA2G10 O15496 BAG3 Homo sapiens O95817
Validated Y2H
32296183
Intra
PLA2G10 O15496 PITX1 Homo sapiens P78337
Validated Y2H
32296183
Intra
PLA2G10 O15496 STK16 Homo sapiens O75716
Validated Y2H
32296183
Intra
PLA2G10 O15496 SNRPC Homo sapiens P09234
Validated Y2H
32296183
Intra
PLA2G10 O15496 ATXN1 Homo sapiens P54253
Validated Y2H
32296183
Intra
PLA2G10 O15496 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
32296183
Intra
PLA2G10 O15496 MAPKBP1 Homo sapiens O60336
Validated Y2H
32296183
Intra
PLA2G10 O15496 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced
Parkinson Disease 14, Autosomal Recessive

PARK14

Dystonia-Parkinsonism, Adult-Onset

Autosomal Recessive Parkinson Disease 14

Parkinson'S Disease 14

Dystonia-Parkinsonism Adult-Onset

Adult-Onset Dystonia-Parkinsonism

Dystonia-Parkinsonism, Paisan-Ruiz Type

Pla2g6-Related Dystonia-Parkinsonism

Parkinson Disease 14

Autosomal Recessive Parkinson'S Disease 14

Nbia/Dyt/Park-Pla2g6

Dystonia-Parkinsonism Paisan-Ruiz Type

Parkinson Disease 14 Autosomal Recessive

Parkinson Disease, Type 14
Meconium Aspiration Syndrome

Neonatal Aspiration Of Meconium

Meconium Aspiration

Mas

Meconium Aspiration Syndrome Of Newborn

Meconium Inhalation

Mas - [Meconium Aspiration Syndrome]

Meconium Aspiration Nos

Meconium Aspiration Syndrome Nos

Meconium Pneumonitis

Meconium Stained Liqueur Aspiration
Acute Chest Syndrome

Acute Chest Syndrome In Sickle Cell Disease
Inhalation Anthrax

Pulmonary Anthrax

Respiratory Anthrax

Inhalational Anthrax

Wool-Sorters' Disease

Woolsorters' Disease

Inhalation Anthrax Disease

Respiratory Anthrax Disease
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10616 PLA2G10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G10 RGD RGD:61935
Canis familiaris PLA2G10 VGNC VGNC:54056
Mus musculus PLA2G10 MGD MGI:1347522
Felis catus PLA2G10 VGNC VGNC:68878