2. Gene
  3. PSMA6 - proteasome 20S subunit alpha 6 Gene

PSMA6 - proteasome 20S subunit alpha 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IOTA; p27K; PROS27

Gene ID: 5687 | Gene type: protein coding

About PSMA6

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,278,558-35,317,493 (from NCBI)

This gene has 17 transcripts (splice variants), 272 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 34.7), colon (RPKM 23.0) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

PSMA6 Products(4)

mRNA Protein Name
NM_001282232.1 NP_001269161.1 proteasome subunit alpha type-6 isoform b
NM_001282233.1 NP_001269162.1 proteasome subunit alpha type-6 isoform b
NM_001282234.1 NP_001269163.1 proteasome subunit alpha type-6 isoform c
NM_002791.3 NP_002782.1 proteasome subunit alpha type-6 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
14743216 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
7681138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12376572 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
16845397 GOA
involved in proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
16845397 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
34711951 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
located in nucleus IDA
IDA: Inferred from direct assay
7681138 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
part of proteasome core complex IDA
IDA: Inferred from direct assay
34711951 GOA
part of proteasome core complex, alpha-subunit complex IDA
IDA: Inferred from direct assay
9096325 GOA
located in ribosome IDA
IDA: Inferred from direct assay
7681138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMA6 Protein Structure

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (9 - 31)

Proteasome

Proteasome: Proteasome subunit (34 - 220)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

proteasome subunit alpha type-6

27 kDa prosomal protein

PSMA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PSMA6 P60900 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra PSMA6 P60900 SMCO3 Homo sapiens A2RU48
Y2H Array
32296183
Intra PSMA6 P60900 SMCO3 Homo sapiens A2RU48
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 RTP5 Homo sapiens Q14D33
Y2H Prey Pooling
25416956
Intra PSMA6 P60900 RTP5 Homo sapiens Q14D33
Y2H Array
25416956
Intra PSMA6 P60900 UCHL5 Homo sapiens Q9Y5K5
Anti Tag CoIP
35271311
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Validated Y2H
32296183
Intra PSMA6 P60900 C19orf47 Homo sapiens Q8N9M1-2
Y2H Array
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra PSMA6 P60900 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra PSMA6 P60900 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra PSMA6 P60900 RNF170 Homo sapiens Q96K19
Validated Y2H
25416956
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Validated Y2H
32296183
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Y2H Array
32296183
Intra PSMA6 P60900 ZKSCAN4 Homo sapiens Q969J2
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Array
32296183
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra PSMA6 P60900 PSMA3 Homo sapiens P25788
Y2H Pooling
16169070
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 PSMD3 Homo sapiens O43242
Y2H Array
32296183
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Pull Down
15225636
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Anti Bait CoIP
19581590
Intra PSMA6 P60900 PSMA4 Homo sapiens P25789
Anti Bait CoIP
17948026
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Validated Y2H
32296183
Intra PSMA6 P60900 POLR2L Homo sapiens P62875
Y2H Array
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Validated Y2H
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 ZNF596 Homo sapiens Q8TC21
Y2H Array
32296183
Intra PSMA6 P60900 CADM1 Homo sapiens Q9BY67
Y2H Array
25416956
Intra PSMA6 P60900 ZBTB44 Homo sapiens Q8NCP5
Validated Y2H
25416956
Intra PSMA6 P60900 ZBTB44 Homo sapiens Q8NCP5
Y2H Array
25416956
Intra PSMA6 P60900 PSMA2 Homo sapiens P25787
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMA2 Homo sapiens P25787
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
14733938
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Pull Down
15225636
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Anti Tag CoIP
35271311
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Anti Bait CoIP
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
17948026
Intra PSMA6 P60900 PSMA7 Homo sapiens O14818
Y2H
15225636
Intra PSMA6 P60900 ERH Homo sapiens P84090
Validated Y2H
32296183
Intra PSMA6 P60900 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 ERH Homo sapiens P84090
Y2H Array
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Y2H Prey Pooling
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Validated Y2H
32296183
Intra PSMA6 P60900 TSPYL Homo sapiens Q6FI91
Y2H Array
32296183
Intra PSMA6 P60900 BRME1 Homo sapiens Q0VDD7
Validated Y2H
25416956
Intra PSMA6 P60900 BRME1 Homo sapiens Q0VDD7
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Combined Oxidative Phosphorylation Deficiency 8

COXPD8

Combined Oxidative Phosphorylation Defect Type 8

Cardiomyopathy, Hypertrophic Mitochondrial, Fatal Infantile

Cardiomyopathy Hypertrophic Mitochondrial Fatal Infantile

Combined Oxidative Phosphorylation Deficiency, Type 8
Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11

Arrhythmogenic Right Ventricular Dysplasia 11

ARVD11

Arrhythmogenic Right Ventricular Cardiomyopathy 11

Arvc11

Arrhythmogenic Right Ventricular Dysplasia 11 With Mild Palmoplantar Keratoderma And Woolly Hair

Arrhythmogenic Right Ventricular Dysplasia, Familial, 11, With Mild Palmoplantar Keratoderma And Woolly Hair

Familial Arrhythmogenic Right Ventricular Dysplasia 11

Arrhythmogenic Right Ventricular Dysplasia 11, Familial, And Mild Palmoplantar Keratoderma And Woolly Hair

ARVD11PK

Arvd And Mild Palmoplantar Keratoderma With Or Without Woolly Hair

Dysplasia, Ventricular, Right, Arrhythmogenic, Type 11
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11296 PSMA6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMA6 RGD RGD:61849
Felis catus PSMA6 VGNC VGNC:80877
Bos taurus PSMA6 VGNC VGNC:33441
Mus musculus PSMA6 MGD MGI:1347006
Canis familiaris PSMA6 VGNC VGNC:45091