PSMC2 - proteasome 26S subunit, ATPase 2 Gene

Homo sapiens

Also known as S7; MSS1; RPT1; Nbla10058

Gene ID: 5701 | Gene type: protein coding

About PSMC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,347,524-103,369,395 (from NCBI)

This gene has 16 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in adrenal (RPKM 22.7), kidney (RPKM 22.5) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in Proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

PSMC2 Products(2)

mRNA	Protein	Name
NM_001204453.1	NP_001191382.1	26S proteasome regulatory subunit 7 isoform 2
NM_002803.4	NP_002794.1	26S proteasome regulatory subunit 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proteasome-activating activity	IDA IDA: Inferred from direct assay	9295362	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	9295362	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	9295362	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

26S proteasome regulatory subunit 7

26S protease regulatory subunit 7

PSMC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMC2	P35998	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	35271311
Intra	PSMC2	P35998	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	22901813
Intra	PSMC2	P35998	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	33961781
Intra	PSMC2	P35998	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	28514442
Intra	PSMC2	P35998	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	22901813
Intra	PSMC2	P35998	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	35271311
Intra	PSMC2	P35998	PSMD2	Homo sapiens	Q13200	Validated Y2H	32296183
Intra	PSMC2	P35998	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	PSMC2	P35998	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	22901813
Intra	PSMC2	P35998	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	35271311
Intra	PSMC2	P35998	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	35271311
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	Validated Y2H	27107012
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	Y2H Array	31515488
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	Validated Y2H	32296183
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	BFG-2H	27107012
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	Anti Tag CoIP	33961781
Intra	PSMC2	P35998	PSMD5	Homo sapiens	Q16401	Y2H Pooling	16189514
Intra	PSMC2	P35998	RAD23B	Homo sapiens	P54727	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina

Amyotrophic Lateral Sclerosis Type 15

Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia	Als15
Amyotrophic Lateral Sclerosis 15

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11311	PSMC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMC2	RGD	RGD:3428
Canis familiaris	PSMC2	VGNC	VGNC:45102
Felis catus	PSMC2	VGNC	VGNC:69112
Macaca mulatta	PSMC2	VGNC	VGNC:108432
Mus musculus	PSMC2	MGD	MGI:109555
Bos taurus	PSMC2	VGNC	VGNC:33455

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