PSMD5 - proteasome 26S subunit, non-ATPase 5 Gene

Homo sapiens

Also known as S5B

Gene ID: 5711 | Gene type: protein coding

About PSMD5

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,816,053-120,842,922 (from NCBI)

This gene has 8 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in urinary bladder (RPKM 4.7), adrenal (RPKM 4.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S Proteasome assembly. [provided by RefSeq, Jul 2012]

PSMD5 Products(2)

mRNA	Protein	Name
NM_001270427.2	NP_001257356.1	26S proteasome non-ATPase regulatory subunit 5 isoform 2
NM_005047.4	NP_005038.1	26S proteasome non-ATPase regulatory subunit 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteasome regulatory particle assembly	IDA IDA: Inferred from direct assay	19490896	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome regulatory particle, base subcomplex	IDA IDA: Inferred from direct assay	19412159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD5 Protein Structure

Proteasom_PSMB

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 5

26S protease subunit S5 basic

PSMD5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD5	Q16401	CASTOR1	Homo sapiens	Q8WTX7	Y2H Prey Pooling	32296183
Intra	PSMD5	Q16401	CASTOR1	Homo sapiens	Q8WTX7	Validated Y2H	32296183
Intra	PSMD5	Q16401	CASTOR1	Homo sapiens	Q8WTX7	Y2H Array	32296183
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	33961781
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Validated Y2H	25416956
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Y2H Prey Pooling	32296183
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	28514442
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Y2H Array	32296183
Intra	PSMD5	Q16401	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	19490896
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	28514442
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H Prey Pooling	25416956
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Validated Y2H	25416956
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	19490896
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H Prey Pooling	32296183
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H	27107012
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H Array	25416956
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	BFG-2H	27107012
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H Array	32296183
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	SLC	27107012
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	33961781
Intra	PSMD5	Q16401	PSMC2	Homo sapiens	P35998	Y2H	21516116
Intra	PSMD5	Q16401	BTBD2	Homo sapiens	Q9BX70	Y2H Array	32296183
Intra	PSMD5	Q16401	BTBD2	Homo sapiens	Q9BX70	Validated Y2H	32296183
Intra	PSMD5	Q16401	BTBD2	Homo sapiens	Q9BX70	Y2H Prey Pooling	32296183
Intra	PSMD5	Q16401	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PSMD5	Q16401	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PSMD5	Q16401	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PSMD5	Q16401	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	PSMD5	Q16401	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	PSMD5	Q16401	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	PSMD5	Q16401	BTBD1	Homo sapiens	Q9H0C5	Y2H Prey Pooling	32296183
Intra	PSMD5	Q16401	BTBD1	Homo sapiens	Q9H0C5	Validated Y2H	32296183
Intra	PSMD5	Q16401	BTBD1	Homo sapiens	Q9H0C5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11326	PSMD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD5	VGNC	VGNC:69125
Mus musculus	PSMD5	MGD	MGI:1914248
Bos taurus	PSMD5	VGNC	VGNC:33469
Macaca mulatta	PSMD5	VGNC	VGNC:76453
Rattus norvegicus	PSMD5	RGD	RGD:1308434

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