2. Gene
  3. MARK4 - microtubule affinity regulating kinase 4 Gene

MARK4 - microtubule affinity regulating kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L

Gene ID: 57787 | Gene type: protein coding

About MARK4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,251,271-45,305,284 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 3 paralogues. Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for Cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MARK4 Products(2)

mRNA Protein Name
NM_001199867.2 NP_001186796.1 MAP/microtubule affinity-regulating kinase 4 isoform 1
NM_031417.4 NP_113605.2 MAP/microtubule affinity-regulating kinase 4 isoform 2

MARK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (59 - 310)

UBA

UBA: UBA/TS-N domain (332 - 366)

KA1

KA1: Kinase associated domain 1 (708 - 752)

  • 0
  • 200
  • 400
  • 600
  • 752 a.a.
Protein Preferred Names Protein Names

MAP/microtubule affinity-regulating kinase 4

MAP/microtubule affinity-regulating kinase like 1

Related Diseases

Diseases Alias
Peutz-Jeghers Syndrome

PJS

Polyposis, Hamartomatous Intestinal

Polyps-And-Spots Syndrome

Lentiginosis, Perioral

Periorificial Lentiginosis Syndrome

Hamartomatous Intestinal Polyposis

Hamartomatous Polyp

Colonic Hamartomatous Polyp

Gastric Peutz-Jeghers Polyp

Peutz Jeghers Colon Polyp

Peutz Jeghers Polyp

Peutz-Jeghers Polyp Of Small Intestine

Peutz-Jeghers Small Bowel Hamartoma

Peutz Jeghers Polyposis

Intestinal Polyposis-Cutaneous Pigmentation Syndrome

Peutz-Jeghers Polyposis

Polyposis, Intestinal, Ii

Intestinal Hamartomatous Polyposis

Peutz-Jeghers Polyp

Peutz-Jeghers Polyp Of The Stomach

Peutz Jehgers Polyp

Peutz-Jeghers Polyps Of Small Bowel
Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset
Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139604 PCC0208017 98.03% Unkown
HY-114317 MARK4 inhibitor 1 98.29% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-154988 MARK4 inhibitor 4 99.23% Unkown
HY-154986 MARK4 inhibitor 2 Inhibitor 99.47% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-154987 MARK4 inhibitor 3 98.23% Unkown
HY-RS08152 MARK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MARK4 VGNC VGNC:74508
Bos taurus MARK4 VGNC VGNC:52203
Mus musculus MARK4 MGD MGI:1920955
Canis familiaris MARK4 VGNC VGNC:43026
Rattus norvegicus MARK4 RGD RGD:1591792
Felis catus MARK4 VGNC VGNC:63390
Others MARK4 NCBI