2. Gene
  3. PTPN9 - protein tyrosine phosphatase non-receptor type 9 Gene

PTPN9 - protein tyrosine phosphatase non-receptor type 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MEG2; PTPMEG2

Gene ID: 5780 | Gene type: protein coding

About PTPN9

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,463,251-75,579,315 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), small intestine (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

PTPN9 Products(1)

mRNA Protein Name
NM_002833.4 NP_002824.1 tyrosine-protein phosphatase non-receptor type 9
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12907755 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
19167335 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
27655914 GOA
acts upstream of or within peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
27655914 GOA
acts upstream of or within positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
27655914 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10940933 GOA
located in neuron projection terminus IDA
IDA: Inferred from direct assay
27655914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN9 Protein Structure

CRAL_TRIO_N

CRAL_TRIO_N: CRAL/TRIO, N-terminal domain (20 - 68)

CRAL_TRIO

CRAL_TRIO: CRAL/TRIO domain (90 - 237)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (327 - 573)

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  • 593 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 9

PTPase-MEG2

Recombinant PTPN9 Proteins

Cat. No. Product Name Accession Purity
HY-P77170 PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST) P43378 (A285-Q593) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11431 PTPN9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPN9 MGD MGI:1928376
Macaca mulatta PTPN9 VGNC VGNC:76609
Rattus norvegicus PTPN9 RGD RGD:628726
Bos taurus PTPN9 VGNC VGNC:33543
Canis familiaris PTPN9 VGNC VGNC:45181
Felis catus PTPN9 VGNC VGNC:69167
Others PTPN9 NCBI