2. Gene
  3. PTPN9 - protein tyrosine phosphatase non-receptor type 9 Gene

PTPN9 - protein tyrosine phosphatase non-receptor type 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MEG2; PTPMEG2

Gene ID: 5780 | Gene type: protein coding

About PTPN9

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,463,251-75,579,315 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), small intestine (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

PTPN9 Products(1)

mRNA Protein Name
NM_002833.4 NP_002824.1 tyrosine-protein phosphatase non-receptor type 9
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12907755 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
19167335 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
27655914 GOA
acts upstream of or within peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
27655914 GOA
acts upstream of or within positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
27655914 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10940933 GOA
located in neuron projection terminus IDA
IDA: Inferred from direct assay
27655914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN9 Protein Structure

CRAL_TRIO_N

CRAL_TRIO_N: CRAL/TRIO, N-terminal domain (20 - 68)

CRAL_TRIO

CRAL_TRIO: CRAL/TRIO domain (90 - 237)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (327 - 573)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 9

PTPase-MEG2

PTPN9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PTPN9 P43378 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra
PTPN9 P43378 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
PTPN9 P43378 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
PTPN9 P43378 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
PTPN9 P43378 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
PTPN9 P43378 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
PTPN9 P43378 COQ3 Homo sapiens Q9NZJ6
Validated Y2H
32296183
Intra
PTPN9 P43378 COQ3 Homo sapiens Q9NZJ6
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 COQ3 Homo sapiens Q9NZJ6
Y2H Array
32296183
Intra
PTPN9 P43378 FAM114A2 Homo sapiens Q9NRY5
Validated Y2H
32296183
Intra
PTPN9 P43378 FAM114A2 Homo sapiens Q9NRY5
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 FAM114A2 Homo sapiens Q9NRY5
Y2H Array
32296183
Intra
PTPN9 P43378 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
PTPN9 P43378 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
PTPN9 P43378 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra
PTPN9 P43378 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
PTPN9 P43378 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
PTPN9 P43378 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
PTPN9 P43378 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197-3
Y2H Array
32296183
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197-3
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
PTPN9 P43378 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
PTPN9 P43378 SLC16A13 Homo sapiens Q7RTY0
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 SLC16A13 Homo sapiens Q7RTY0
Validated Y2H
32296183
Intra
PTPN9 P43378 SLC16A13 Homo sapiens Q7RTY0
Y2H Array
32296183
Intra
PTPN9 P43378 TMCO2 Homo sapiens Q7Z6W1
Y2H Array
32296183
Intra
PTPN9 P43378 TMCO2 Homo sapiens Q7Z6W1
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 TMCO2 Homo sapiens Q7Z6W1
Validated Y2H
32296183
Intra
PTPN9 P43378 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
PTPN9 P43378 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
PTPN9 P43378 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra
PTPN9 P43378 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra
PTPN9 P43378 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 CMTM4 Homo sapiens Q8IZR5-2
Validated Y2H
32296183
Intra
PTPN9 P43378 CMTM4 Homo sapiens Q8IZR5-2
Y2H Array
32296183
Intra
PTPN9 P43378 CMTM4 Homo sapiens Q8IZR5-2
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
PTPN9 P43378 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
PTPN9 P43378 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
PTPN9 P43378 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
PTPN9 P43378 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
PTPN9 P43378 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra
PTPN9 P43378 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
PTPN9 P43378 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
PTPN9 P43378 ATP5PF Homo sapiens P18859
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 ATP5PF Homo sapiens P18859
Y2H Array
32296183
Intra
PTPN9 P43378 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
PTPN9 P43378 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
PTPN9 P43378 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
PTPN9 P43378 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
PTPN9 P43378 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
PTPN9 P43378 CDR1 Homo sapiens P51861
Y2H Array
32296183
Intra
PTPN9 P43378 CDR1 Homo sapiens P51861
Validated Y2H
32296183
Intra
PTPN9 P43378 CDR1 Homo sapiens P51861
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
PTPN9 P43378 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
PTPN9 P43378 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
PTPN9 P43378 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
PTPN9 P43378 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
PTPN9 P43378 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
PTPN9 P43378 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
PTPN9 P43378 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
PTPN9 P43378 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
PTPN9 P43378 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
PTPN9 P43378 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
PTPN9 P43378 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 NSF Homo sapiens P46459
Pull Down
15322554
Intra
PTPN9 P43378 NSF Homo sapiens P46459
Phosphatase Assay
15322554
Intra
PTPN9 P43378 ARL6IP1 Homo sapiens Q15041
Validated Y2H
32296183
Intra
PTPN9 P43378 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Intra
PTPN9 P43378 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 PLIN3 Homo sapiens O60664
Y2H Array
32296183
Intra
PTPN9 P43378 PLIN3 Homo sapiens O60664
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197
Validated Y2H
25416956
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197
Y2H Array
25416956
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197
Y2H Pooling
16189514
Intra
PTPN9 P43378 RTN3 Homo sapiens O95197
Y2H Prey Pooling
25416956
Intra
PTPN9 P43378 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra
PTPN9 P43378 PBX3 Homo sapiens Q96AL5
Y2H Array
32296183
Intra
PTPN9 P43378 PBX3 Homo sapiens Q96AL5
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
PTPN9 P43378 DERL2 Homo sapiens Q9GZP9
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 DERL2 Homo sapiens Q9GZP9
Validated Y2H
32296183
Intra
PTPN9 P43378 DERL2 Homo sapiens Q9GZP9
Y2H Array
32296183
Intra
PTPN9 P43378 BSND Homo sapiens Q8WZ55
Validated Y2H
32296183
Intra
PTPN9 P43378 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
PTPN9 P43378 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 SYP Homo sapiens P08247
Y2H Array
32296183
Intra
PTPN9 P43378 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 MAL2 Homo sapiens Q969L2
Validated Y2H
25416956
Intra
PTPN9 P43378 MAL2 Homo sapiens Q969L2
Y2H Array
25416956
Intra
PTPN9 P43378 MAL2 Homo sapiens Q969L2
Y2H Prey Pooling
25416956
Intra
PTPN9 P43378 SCAMP1 Homo sapiens O15126
Y2H Prey Pooling
32296183
Intra
PTPN9 P43378 SCAMP1 Homo sapiens O15126
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN9 Proteins

Cat. No. Product Name Accession Purity
HY-P77170 PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST) P43378 (A285-Q593) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11431 PTPN9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPN9 MGD MGI:1928376
Macaca mulatta PTPN9 VGNC VGNC:76609
Rattus norvegicus PTPN9 RGD RGD:628726
Bos taurus PTPN9 VGNC VGNC:33543
Canis familiaris PTPN9 VGNC VGNC:45181
Felis catus PTPN9 VGNC VGNC:69167
Others PTPN9 NCBI