RAB3IL1 - RAB3A interacting protein like 1 Gene

Homo sapiens

Also known as GRAB

Gene ID: 5866 | Gene type: protein coding

About RAB3IL1

This gene has 6 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in testis (RPKM 14.8), ovary (RPKM 10.2) and 24 other tissues.

Summary

This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]

RAB3IL1 Products(2)

mRNA	Protein	Name
NM_001271686.2	NP_001258615.1	guanine nucleotide exchange factor for Rab-3A isoform 2
NM_013401.4	NP_037533.2	guanine nucleotide exchange factor for Rab-3A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	20937701	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB3IL1 Protein Structure

Sec2p

0
100
200
300
382 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide exchange factor for Rab-3A

RAB3A interacting protein (rabin3)-like 1

RAB3IL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB3IL1	Q8TBN0	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	RAB3IL1	Q8TBN0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
Intra	RAB3IL1	Q8TBN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	TTC7B	Homo sapiens	Q86TV6	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	TTC7B	Homo sapiens	Q86TV6	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	CCDC57	Homo sapiens	Q2TAC2	Validated Y2H	25416956
Intra	RAB3IL1	Q8TBN0	CCDC57	Homo sapiens	Q2TAC2	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	RAB3IL1	Q8TBN0	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	RAB3IL1	Q8TBN0	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	RAB3IL1	Q8TBN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	TIGD7	Homo sapiens	Q6NT04	Validated Y2H	25416956
Intra	RAB3IL1	Q8TBN0	TIGD7	Homo sapiens	Q6NT04	Y2H Prey Pooling	25416956
Intra	RAB3IL1	Q8TBN0	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	RAB3IL1	Q8TBN0	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	16189514
Intra	RAB3IL1	Q8TBN0	NUDT18	Homo sapiens	Q6ZVK8	Y2H Array	19060904
Intra	RAB3IL1	Q8TBN0	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	19060904
Intra	RAB3IL1	Q8TBN0	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Y2H Pooling	16189514
Intra	RAB3IL1	Q8TBN0	RAB3IL1	Homo sapiens	Q8TBN0	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	RAB3IL1	Homo sapiens	Q8TBN0	Y2H Pooling	16189514
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	19060904
Intra	RAB3IL1	Q8TBN0	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Y2H Prey Pooling	25416956
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Y2H Pooling	19060904
Intra	RAB3IL1	Q8TBN0	TMEM102	Homo sapiens	Q8N9M5	Anti Tag CoIP	28514442
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956
Intra	RAB3IL1	Q8TBN0	RAB3IL1	Homo sapiens	Q8TBN0	Y2H Array	31515488
Intra	RAB3IL1	Q8TBN0	RAB3IP	Homo sapiens	Q96QF0	Anti Tag CoIP	33961781
Intra	RAB3IL1	Q8TBN0	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	CTDSP1	Homo sapiens	Q9GZU7	Validated Y2H	32296183
Intra	RAB3IL1	Q8TBN0	CTDSP1	Homo sapiens	Q9GZU7	Y2H Prey Pooling	32296183
Intra	RAB3IL1	Q8TBN0	CTDSP1	Homo sapiens	Q9GZU7	Y2H Array	32296183
Intra	RAB3IL1	Q8TBN0	SATB2	Homo sapiens	Q9UPW6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20	SCA20
Spinocerebellar Ataxia With Dysphonia	Spinocerebellar Ataxia With Spasmodic Cough
Chromosome 11q12 Duplication Syndrome, 260-Kb	Chromosome 11q12 Duplication Syndrome 260-Kb

Achondrogenesis

Achondrogenesis Syndrome

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11561	RAB3IL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB3IL1	RGD	RGD:619764
Macaca mulatta	RAB3IL1	VGNC	VGNC:76638
Felis catus	RAB3IL1	VGNC	VGNC:69204
Canis familiaris	RAB3IL1	VGNC	VGNC:45288
Mus musculus	RAB3IL1	MGD	MGI:1922010
Bos taurus	RAB3IL1	VGNC	VGNC:33655

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