Dact1 - dishevelled-binding antagonist of beta-catenin 1 Gene

Mus musculus

Also known as Frd1; FRODO; MDpr1; MTNG3; DAPPER; Frodo1; THYEX3; DAPPER1; 4921528D17Rik

Gene ID: 59036 | Gene type: protein coding

About Dact1

Summary

Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in embryonic hindgut morphogenesis and regulation of signal transduction. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dact1 Products(2)

mRNA	Protein	Name
NM_001190466.1	NP_001177395.1	dapper homolog 1 isoform 1
NM_021532.4	NP_067507.2	dapper homolog 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delta-catenin binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11970895	MGI
enables protein kinase A binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables protein kinase C binding	IDA IDA: Inferred from direct assay	21718540	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20145239	MGI
acts upstream of or within dendrite morphogenesis	IGI IGI: Inferred from genetic interaction	20335472	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	20335472	MGI
involved in embryonic hindgut morphogenesis	IMP IMP: Inferred from mutant phenotype	20145239	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	19701191	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	19701191	MGI
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	17197390	MGI
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	17197390	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19073771	MGI
acts upstream of or within positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	19073771	MGI
acts upstream of or within regulation of Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	19701191	MGI
involved in regulation of Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	20145239	MGI
NOT involved in regulation of nodal signaling pathway	IDA IDA: Inferred from direct assay	17197390	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	20335472	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	20335472	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	20335472	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20335472	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	20335472	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20335472	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	20335472	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	20335472	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dapper homolog 1

dapper 1	dapper antagonist of catenin 1
dapper homolog 1, antagonist of beta-catenin	frodo homolog
thymus expressed gene 3	thymus-expressed novel gene 3 protein

Dact1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dact1	Q8R4A3	Dvl1	Mus musculus	P51141	Pull Down	14636582
Intra	Dact1	Q8R4A3	Dvl1	Mus musculus	P51141	Anti Tag CoIP	21718540
Intra	Dact1	Q8R4A3	Dvl1	Mus musculus	P51141	Fluorescence Spectr	14636582
Intra	Dact1	Q8R4A3	Vangl2	Mus musculus	Q91ZD4	Anti Tag CoIP	21718540
Intra	Dact1	Q8R4A3	Vangl2	Mus musculus	Q91ZD4	Pull Down	19701191
Intra	Dact1	Q8R4A3	Dact3	Mus musculus	Q0PHV7	Anti Tag CoIP	21718540
Intra	Dact1	Q8R4A3	Dvl2	Mus musculus	Q60838	Anti Tag CoIP	19701191

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03515	DACT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dact1	NCBI	NCBI:51339

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