Vangl2 - VANGL planar cell polarity 2 Gene

Mus musculus

Also known as Lp; Lpp1; Ltap; stbm; Lootl; ska17; Vang1l2; loop-tail; strabismus; ska; C530001F03Rik

Gene ID: 93840 | Gene type: protein coding

About Vangl2

Summary

Involved in axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Acts upstream of or within several processes, including animal organ development; morphogenesis of an epithelium; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vangl2 Products(1)

mRNA	Protein	Name
NM_033509.4	NP_277044.1	vang-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15195140	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	16116426	MGI
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	18849982	MGI
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	16495441	MGI
involved in cell migration involved in kidney development	IMP IMP: Inferred from mutant phenotype	20534871	MGI
acts upstream of or within cochlea development	IGI IGI: Inferred from genetic interaction	18066062	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	16116426	MGI
acts upstream of or within convergent extension involved in axis elongation	IMP IMP: Inferred from mutant phenotype	17229766	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IGI IGI: Inferred from genetic interaction	16571627	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IMP IMP: Inferred from mutant phenotype	16571627	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within digestive tract morphogenesis	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in dopaminergic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within establishment of body hair planar orientation	IMP IMP: Inferred from mutant phenotype	18849982	MGI
acts upstream of or within establishment of planar polarity	IGI IGI: Inferred from genetic interaction	20643356	MGI
involved in establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	12724779	MGI
acts upstream of or within establishment of planar polarity involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	18606138	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	17376975	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	20843830	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	18849982	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	11440971	MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	23760952	MGI
acts upstream of or within inner ear receptor cell development	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	18066062	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	18606138	MGI
acts upstream of or within kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	20843830	MGI
acts upstream of or within lateral sprouting involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within membranous septum morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within muscular septum morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	14512015	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	11709546	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19497282	MGI
acts upstream of or within non-motile cilium assembly	IGI IGI: Inferred from genetic interaction	16170314	MGI
acts upstream of or within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within positive regulation of JUN kinase activity	IGI IGI: Inferred from genetic interaction	15195140	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	21761479	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within regulation of establishment of planar polarity	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in regulation of synapse pruning	IDA IDA: Inferred from direct assay	34407949	MGI
involved in regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	34407949	MGI
involved in serotonergic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within somatic stem cell division	IMP IMP: Inferred from mutant phenotype	19497282	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19497282	MGI
acts upstream of or within wound healing	IGI IGI: Inferred from genetic interaction	20643356	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in COPII-coated ER to Golgi transport vesicle	IDA IDA: Inferred from direct assay	19966784	MGI
located in apical cytoplasm	IDA IDA: Inferred from direct assay	25333478	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16687519	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20534871	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	20215345	MGI
located in cell pole	IDA IDA: Inferred from direct assay	19497282	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	15195140	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34407949	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	17433286	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16962386	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	34407949	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	24302887	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vang-like protein 2

loop tail associated protein	loop-tail protein 1
van Gogh-like protein 2	vang-like 2 (van gogh, Drosophila)

Vangl2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Vangl2	Q91ZD4	Dvl1	Mus musculus	P51141	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dvl3	Mus musculus	Q61062	Y2H	15456783
Intra	Vangl2	Q91ZD4	Dvl3	Mus musculus	Q61062	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	19701191
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Anti Bait CoIP	15456783
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Anti Tag CoIP	19701191
Cross	Vangl2	Q91ZD4	Dlg4	Rattus norvegicus	P31016	Pull Down	23567299
Cross	Vangl2	Q91ZD4	Dlg4	Rattus norvegicus	P31016	Anti Tag CoIP	23567299

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15601	VANGL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vangl2	NCBI	NCBI:57216

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