RFC5 - replication factor C subunit 5 Gene

Homo sapiens

Also known as RFC36

Gene ID: 5985 | Gene type: protein coding

About RFC5

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,016,703-118,041,448 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

RFC5 Products(6)

mRNA	Protein	Name
NM_001130112.4	NP_001123584.1	replication factor C subunit 5 isoform 3
NM_001130113.3	NP_001123585.1	replication factor C subunit 5 isoform 2
NM_001206801.3	NP_001193730.1	replication factor C subunit 5 isoform 4
NM_001346815.2	NP_001333744.1	replication factor C subunit 5 isoform 5
NM_007370.7	NP_031396.1	replication factor C subunit 5 isoform 1
NM_181578.5	NP_853556.2	replication factor C subunit 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA clamp loader activity	IDA IDA: Inferred from direct assay	12930902	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9488738	GOA
contributes to single-stranded DNA helicase activity	IDA IDA: Inferred from direct assay	12930902	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	9488738	GOA
involved in positive regulation of DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	12930902	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ctf18 RFC-like complex	IDA IDA: Inferred from direct assay	12930902	GOA
part of DNA replication factor C complex	IDA IDA: Inferred from direct assay	9488738	GOA
part of DNA replication factor C complex	IPI IPI: Inferred from physical interaction	9488738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RFC5 Protein Structure

AAA

Rep_fac_C

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

replication factor C subunit 5

A1 36 kDa subunit

RFC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RFC5	P40937	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	RFC5	P40937	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
Intra	RFC5	P40937	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	RFC5	P40937	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	RFC5	P40937	LMO3	Homo sapiens	Q8TAP4-4	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32296183
Intra	RFC5	P40937	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Array	32296183
Intra	RFC5	P40937	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	ZNF19	Homo sapiens	P17023	Y2H Array	32296183
Intra	RFC5	P40937	ZNF19	Homo sapiens	P17023	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	TRIM38	Homo sapiens	O00635	Y2H Array	32296183
Intra	RFC5	P40937	TRIM38	Homo sapiens	O00635	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	RFC5	P40937	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	RFC5	P40937	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	N4BP3	Homo sapiens	O15049	Y2H Array	32296183
Intra	RFC5	P40937	N4BP3	Homo sapiens	O15049	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	RFC5	P40937	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	RFC5	P40937	XAF1	Homo sapiens	Q6GPH4	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	XAF1	Homo sapiens	Q6GPH4	Validated Y2H	32296183
Intra	RFC5	P40937	XAF1	Homo sapiens	Q6GPH4	Y2H Array	32296183
Intra	RFC5	P40937	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	RFC5	P40937	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	RFC5	P40937	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	CCNC	Homo sapiens	P24863	Y2H Array	32296183
Intra	RFC5	P40937	MEAF6	Homo sapiens	Q9HAF1	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	MEAF6	Homo sapiens	Q9HAF1	Validated Y2H	32296183
Intra	RFC5	P40937	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	32296183
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Anti Tag CoIP	33961781
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Anti Tag CoIP	28514442
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Validated Y2H	25416956
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Y2H Prey Pooling	25416956
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Y2H Array	25416956
Intra	RFC5	P40937	RFC4	Homo sapiens	P35249	Y2H Array	32296183
Intra	RFC5	P40937	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	BIRC2	Homo sapiens	Q13490	Validated Y2H	32296183
Intra	RFC5	P40937	BIRC2	Homo sapiens	Q13490	Y2H Array	32296183
Intra	RFC5	P40937	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	XIAP	Homo sapiens	P98170	Validated Y2H	32296183
Intra	RFC5	P40937	XIAP	Homo sapiens	P98170	Y2H Array	25416956
Intra	RFC5	P40937	XIAP	Homo sapiens	P98170	Y2H Array	32296183
Intra	RFC5	P40937	XIAP	Homo sapiens	P98170	Y2H Array	31515488
Intra	RFC5	P40937	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	RFC5	P40937	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	RFC5	P40937	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
Intra	RFC5	P40937	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	RFC5	P40937	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	TASOR2	Homo sapiens	Q5VWN6	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	TASOR2	Homo sapiens	Q5VWN6	Validated Y2H	32296183
Intra	RFC5	P40937	TASOR2	Homo sapiens	Q5VWN6	Y2H Array	32296183
Intra	RFC5	P40937	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	RFC5	P40937	NAB2	Homo sapiens	Q15742	Validated Y2H	25416956
Intra	RFC5	P40937	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	NAB2	Homo sapiens	Q15742	Validated Y2H	32296183
Intra	RFC5	P40937	NAB2	Homo sapiens	Q15742	Y2H Array	25416956
Intra	RFC5	P40937	NR5A1	Homo sapiens	Q13285	Y2H Array	32296183
Intra	RFC5	P40937	NR5A1	Homo sapiens	Q13285	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	NR5A1	Homo sapiens	Q13285	Validated Y2H	32296183
Intra	RFC5	P40937	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	RFC5	P40937	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	RFC5	P40937	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11869	RFC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RFC5	VGNC	VGNC:76904
Rattus norvegicus	RFC5	RGD	RGD:1309280
Mus musculus	RFC5	MGD	MGI:1919401
Felis catus	RFC5	VGNC	VGNC:69298
Canis familiaris	RFC5	VGNC	VGNC:45496
Bos taurus	RFC5	VGNC	VGNC:33889

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