1. Gene
  2. Prmt1 - protein arginine methyltransferase 1 Gene

Prmt1 - protein arginine methyltransferase 1 Gene

Rattus norvegicus

Also known as Hrmt1l2

Gene ID: 60421 | Gene type: protein coding

About Prmt1

Primary_assembly 1: 95,458,850-95,468,345 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 190 orthologues, 10 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 215.1), Heart (RPKM 24.5) and 9 other tissues.

Summary

Enables identical protein binding activity; protein-arginine N-methyltransferase activity; and snoRNP binding activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol; membrane; and nucleus. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products(1)

mRNA Protein Name
NM_024363.1 NP_077339.1 protein arginine N-methyltransferase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
12737817 RGD
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
8663146 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9642256 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10749851 RGD
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
8663146 RGD
enables protein-arginine N-methyltransferase activity IDA
IDA: Inferred from direct assay
10899106 RGD
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
IDA: Inferred from direct assay
8663146 RGD
enables protein-arginine omega-N monomethyltransferase activity IDA
IDA: Inferred from direct assay
8663146 RGD
enables snoRNP binding IDA
IDA: Inferred from direct assay
12523648 RGD
Biological Process GO Annotation Evidence Reference Source
involved in S-adenosylmethionine metabolic process IDA
IDA: Inferred from direct assay
12737817 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
15837430 RGD
involved in peptidyl-arginine methylation IDA
IDA: Inferred from direct assay
8663146 RGD
acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
IDA: Inferred from direct assay
8663146 RGD
involved in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
IDA: Inferred from direct assay
8663146 RGD
acts upstream of or within peptidyl-arginine omega-N-methylation IDA
IDA: Inferred from direct assay
8663146 RGD
involved in positive regulation of erythrocyte differentiation IDA
IDA: Inferred from direct assay
23483889 RGD
involved in positive regulation of hemoglobin biosynthetic process IDA
IDA: Inferred from direct assay
23483889 RGD
involved in positive regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
23483889 RGD
acts upstream of or within protein methylation IDA
IDA: Inferred from direct assay
10749851 RGD
involved in protein methylation IDA
IDA: Inferred from direct assay
23483889 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
15837430 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15837430 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt1 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (91 - 191)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 1

heterogeneous nuclear ribonucleoproteins methyltransferase-like 2

histone-arginine N-methyltransferase PRMT1

Prmt1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Prmt1 Q63009 Prmt1 Rattus norvegicus Q63009
Y2H
9642256
Intra
Prmt1 Q63009 Prmt1 Rattus norvegicus Q63009 20345902
Intra
Prmt1 Q63009 Btg2 Rattus norvegicus P27049
Y2H
9642256
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt1 NCBI NCBI:3276