RPE - ribulose-5-phosphate-3-epimerase Gene

Homo sapiens

Also known as RPE2-1

Gene ID: 6120 | Gene type: protein coding

About RPE

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,002,638-210,022,260 (from NCBI)

This gene has 16 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.9), adrenal (RPKM 5.7) and 25 other tissues.

Summary

Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RPE Products(14)

mRNA	Protein	Name
NM_001278282.2	NP_001265211.1	ribulose-phosphate 3-epimerase isoform 2
NM_001278283.2	NP_001265212.1	ribulose-phosphate 3-epimerase isoform 2
NM_001278285.2	NP_001265214.1	ribulose-phosphate 3-epimerase isoform 3
NM_001278286.2	NP_001265215.1	ribulose-phosphate 3-epimerase isoform 4
NM_001278288.2	NP_001265217.1	ribulose-phosphate 3-epimerase isoform 4
NM_001278289.2	NP_001265218.1	ribulose-phosphate 3-epimerase isoform 5
NM_001318926.2	NP_001305855.1	ribulose-phosphate 3-epimerase isoform 6
NM_001318927.2	NP_001305856.1	ribulose-phosphate 3-epimerase isoform 7
NM_001318928.2	NP_001305857.1	ribulose-phosphate 3-epimerase isoform 8
NM_001318929.2	NP_001305858.1	ribulose-phosphate 3-epimerase isoform 9
NM_001318930.2	NP_001305859.1	ribulose-phosphate 3-epimerase isoform 4
NM_001318931.2	NP_001305860.1	ribulose-phosphate 3-epimerase isoform 4
NM_006916.3	NP_008847.1	ribulose-phosphate 3-epimerase isoform 2
NM_199229.3	NP_954699.1	ribulose-phosphate 3-epimerase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-ribulose-phosphate 3-epimerase activity	IDA IDA: Inferred from direct assay	20923965	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables metal ion binding	IDA IDA: Inferred from direct assay	20923965	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20923965	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in carbohydrate metabolic process	IDA IDA: Inferred from direct assay	20923965	GOA
involved in pentose-phosphate shunt	IDA IDA: Inferred from direct assay	20923965	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPE Protein Structure

Ribul_P_3_epim

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

ribulose-phosphate 3-epimerase

RPE Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPE	Q96AT9	CLU	Homo sapiens	P10909	Anti Tag CoIP	33961781
Intra	RPE	Q96AT9	serB2	Yersinia pestis	A0A6B3V8E0	Y2H Pooling	20711500
Intra	RPE	Q96AT9	GPX4	Homo sapiens	P36969	Anti Tag CoIP	33961781
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	Y2H Pooling	16189514
Intra	RPE	Q96AT9	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	Validated Y2H	32296183
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	X-Ray Diffraction	20923965
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	Y2H Array	25416956
Intra	RPE	Q96AT9	APOD	Homo sapiens	P05090	Anti Tag CoIP	33961781
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	Y2H Prey Pooling	32296183
Intra	RPE	Q96AT9	GCD7	Saccharomyces cerevisiae	P32502	Y2H Array	27107014
Intra	RPE	Q96AT9	RPE	Homo sapiens	Q96AT9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71264	RPE Protein, Human (His)	Q96AT9-1 (M1-R228)	≥95%
HY-P74592	RPE Protein, Human (HEK293, His)	Q96AT9-1/NP_954699.1 (M1-R228)	≥95%

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148457	Avacincaptad pegol	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19720A	Emixustat hydrochloride		99.29%	Phase 3
HY-19720	Emixustat	Inhibitor	98.00%	Phase 3
HY-101019	Ossirene	Inhibitor	≥98.0%	Phase 2
HY-125639	(rac)-AR-13503	Inhibitor	98.01%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134928A	Pyridinium bisretinoid A2E TFA		≥90.0%	Unkown
HY-N0428	Obacunone	Inducer	99.75%	Unkown
HY-D0988	R-PE (R-Phycoerythrin)		/	Unkown
HY-D1742	DRAQ5	Chemical	/	Unkown
HY-101293	VU0359595	Inhibitor	99.65%	Unkown
HY-12462	WS3		98.00%	Unkown
HY-22024	5-Hydroxyflavone		99.83%	Unkown
HY-149325	RPE65-IN-1		≥98.0%	Unkown
HY-163684	Zoracopan	Inhibitor	99.85%	Unkown
HY-134928	Pyridinium bisretinoid A2E		/	Unkown
HY-P5169A	LVGRQLEEFL (mouse) (TFA)		98.20%	Unkown
HY-151872	HDAC-IN-48		/	Unkown
HY-162904	BPU17		/	Unkown
HY-N11499	Myricetin 3-O-α-L-arabinopyranoside	Inhibitor	/	Unkown
HY-P4253	Arginyl-Glutamine	Inhibitor	/	Unkown
HY-P5169	LVGRQLEEFL (mouse)		/	Unkown
HY-RS12150	RPE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12151	RPE65 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2396	Sulfo SMCC R-phycoerythrin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPE	MGD	MGI:1913896
Rattus norvegicus	RPE	RGD	RGD:1564890
Macaca mulatta	RPE	NCBI	NCBI:711322

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