BET1 - Bet1 golgi vesicular membrane trafficking protein Gene

Homo sapiens

Also known as HBET1

Gene ID: 10282 | Gene type: protein coding

About BET1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,962,762-94,004,355 (from NCBI)

This gene has 8 transcripts (splice variants) and 76 orthologues. Ubiquitous expression in placenta (RPKM 6.4), adrenal (RPKM 5.3) and 25 other tissues.

Summary

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

BET1 Products(2)

mRNA	Protein	Name
NM_001317739.2	NP_001304668.1	BET1 homolog isoform 2
NM_005868.6	NP_005859.1	BET1 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	34779586	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cis-Golgi network	IDA IDA: Inferred from direct assay	34779586	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34779586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BET1 Protein Structure

SNARE

0
100
118 a.a.

Protein Preferred Names

Protein Names

BET1 homolog

Bet1p homolog

BET1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BET1	O15155	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	BET1	O15155	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	BET1	O15155	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	BET1	O15155	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	BET1	O15155	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	BET1	O15155	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	BET1	O15155	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	BET1	O15155	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	BET1	O15155	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	BET1	O15155	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	BET1	O15155	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	BET1	O15155	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	BET1	O15155	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	BET1	O15155	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	BET1	O15155	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	BET1	O15155	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMEM35A	Homo sapiens	Q53FP2	Validated Y2H	32296183
Intra	BET1	O15155	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	BET1	O15155	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	BET1	O15155	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	BET1	O15155	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	BET1	O15155	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	BET1	O15155	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	BET1	O15155	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	BET1	O15155	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	BET1	O15155	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	BET1	O15155	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	BET1	O15155	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	BET1	O15155	CD74	Homo sapiens	P04233-2	Validated Y2H	32296183
Intra	BET1	O15155	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	BET1	O15155	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	ASZ1	Homo sapiens	Q8WWH4	Y2H Array	32296183
Intra	BET1	O15155	ASZ1	Homo sapiens	Q8WWH4	Y2H Prey Pooling	32296183
Intra	BET1	O15155	ASZ1	Homo sapiens	Q8WWH4	Validated Y2H	32296183
Intra	BET1	O15155	ASGR2	Homo sapiens	P07307-3	Validated Y2H	32296183
Intra	BET1	O15155	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	BET1	O15155	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	BET1	O15155	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Prey Pooling	32296183
Intra	BET1	O15155	SLC26A6	Homo sapiens	Q9BXS9-3	Validated Y2H	32296183
Intra	BET1	O15155	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Array	32296183
Intra	BET1	O15155	TMCO5A	Homo sapiens	Q8N6Q1	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMCO5A	Homo sapiens	Q8N6Q1	Validated Y2H	32296183
Intra	BET1	O15155	TMCO5A	Homo sapiens	Q8N6Q1	Y2H Array	32296183
Intra	BET1	O15155	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	BET1	O15155	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	BET1	O15155	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	BET1	O15155	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	BET1	O15155	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	BET1	O15155	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
Intra	BET1	O15155	LYPD5	Homo sapiens	Q6UWN5	Validated Y2H	32296183
Intra	BET1	O15155	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CRB3	Homo sapiens	Q9BUF7-2	Validated Y2H	32296183
Intra	BET1	O15155	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	BET1	O15155	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	BET1	O15155	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	BET1	O15155	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	BET1	O15155	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	BET1	O15155	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	BET1	O15155	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	BET1	O15155	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	BET1	O15155	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	BET1	O15155	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	BET1	O15155	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	BET1	O15155	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	BET1	O15155	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	BET1	O15155	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	BET1	O15155	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	BET1	O15155	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	BET1	O15155	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	BET1	O15155	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	BET1	O15155	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	BET1	O15155	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	BET1	O15155	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	BET1	O15155	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	BET1	O15155	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	BET1	O15155	CLEC10A	Homo sapiens	Q8IUN9	Validated Y2H	32296183
Intra	BET1	O15155	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	BET1	O15155	ADORA2A	Homo sapiens	P29274	Y2H Prey Pooling	32296183
Intra	BET1	O15155	ADORA2A	Homo sapiens	P29274	Validated Y2H	32296183
Intra	BET1	O15155	ADORA2A	Homo sapiens	P29274	Y2H Array	32296183
Intra	BET1	O15155	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	BET1	O15155	GOSR2	Homo sapiens	O14653	Pull Down	29568061
Intra	BET1	O15155	GOSR2	Homo sapiens	O14653	Y2H Prey Pooling	32296183
Intra	BET1	O15155	GOSR2	Homo sapiens	O14653	Anti Tag CoIP	33961781
Intra	BET1	O15155	GOSR2	Homo sapiens	O14653	BioID	29568061
Intra	BET1	O15155	GOSR2	Homo sapiens	O14653	Y2H Array	32296183
Intra	BET1	O15155	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	BET1	O15155	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	BET1	O15155	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	BET1	O15155	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	BET1	O15155	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	BET1	O15155	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	BET1	O15155	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	BET1	O15155	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	BET1	O15155	ANKS6	Homo sapiens	Q68DC2	Validated Y2H	32296183
Intra	BET1	O15155	ANKS6	Homo sapiens	Q68DC2	Y2H Array	32296183
Intra	BET1	O15155	ANKS6	Homo sapiens	Q68DC2	Y2H Prey Pooling	32296183
Intra	BET1	O15155	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	BET1	O15155	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	BET1	O15155	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	BET1	O15155	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	BET1	O15155	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	BET1	O15155	USHBP1	Homo sapiens	Q8N6Y0	Pull Down	16189514
Intra	BET1	O15155	USHBP1	Homo sapiens	Q8N6Y0	Y2H Pooling	16189514
Intra	BET1	O15155	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	BET1	O15155	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	BET1	O15155	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	BET1	O15155	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
Intra	BET1	O15155	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	BET1	O15155	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
Intra	BET1	O15155	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	BET1	O15155	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	BET1	O15155	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	BET1	O15155	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	BET1	O15155	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	BET1	O15155	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	BET1	O15155	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	BET1	O15155	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	BET1	O15155	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	BET1	O15155	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	BET1	O15155	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	BET1	O15155	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	BET1	O15155	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	BET1	O15155	CYB561	Homo sapiens	P49447	Validated Y2H	32296183
Intra	BET1	O15155	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	BET1	O15155	STX1B	Homo sapiens	P61266	Y2H Prey Pooling	32296183
Intra	BET1	O15155	STX1B	Homo sapiens	P61266	Validated Y2H	32296183
Intra	BET1	O15155	STX1B	Homo sapiens	P61266	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Citrullinemia, Type Ii, Neonatal-Onset

NICCD	Citrin Deficiency
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia
Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency	Neonatal-Onset Type Ii Citrullinemia
Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency	Neonatal-Onset Citrullinemia Type 2
Neonatal-Onset Citrullinemia Type Ii	Neonatal-Onset Type 2 Citrullinemia
Adult-Onset Citrullinemia Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135250B	Thalidomide-4-O-C6-NH2 hydrochloride	Inducer	98.53%	Unkown
HY-142265	NVS-BET-1	Inhibitor	/	Unkown
HY-135250A	Thalidomide-4-O-C6-NH2 TFA	Inducer	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-157749	Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3	Inducer	/	Unkown
HY-RS01478	BET1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01479	BET1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BET1	VGNC	VGNC:26475
Rattus norvegicus	BET1	RGD	RGD:2203
Mus musculus	BET1	MGD	MGI:1343104
Macaca mulatta	BET1	VGNC	VGNC:80799

Name
Email *

	Sorry, but the email address you supplied was invalid.