BET1 - Bet1 golgi vesicular membrane trafficking protein Gene

Homo sapiens

Also known as HBET1

Gene ID: 10282 | Gene type: protein coding

About BET1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,962,762-94,004,355 (from NCBI)

This gene has 8 transcripts (splice variants) and 76 orthologues. Ubiquitous expression in placenta (RPKM 6.4), adrenal (RPKM 5.3) and 25 other tissues.

Summary

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

BET1 Products(2)

mRNA	Protein	Name
NM_001317739.2	NP_001304668.1	BET1 homolog isoform 2
NM_005868.6	NP_005859.1	BET1 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	34779586	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cis-Golgi network	IDA IDA: Inferred from direct assay	34779586	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34779586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BET1 Protein Structure

SNARE

0
100
118 a.a.

Protein Preferred Names

Protein Names

BET1 homolog

Bet1p homolog

Related Diseases

Diseases

Alias

Citrullinemia, Type Ii, Neonatal-Onset

NICCD	Citrin Deficiency
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia
Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency	Neonatal-Onset Type Ii Citrullinemia
Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency	Neonatal-Onset Citrullinemia Type 2
Neonatal-Onset Citrullinemia Type Ii	Neonatal-Onset Type 2 Citrullinemia
Adult-Onset Citrullinemia Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135250B	Thalidomide-4-O-C6-NH2 hydrochloride	Inducer	98.53%	Unkown
HY-142265	NVS-BET-1	Inhibitor	/	Unkown
HY-135250A	Thalidomide-4-O-C6-NH2 TFA	Inducer	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-157749	Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3	Inducer	/	Unkown
HY-RS01478	BET1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01479	BET1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BET1	VGNC	VGNC:26475
Rattus norvegicus	BET1	RGD	RGD:2203
Mus musculus	BET1	MGD	MGI:1343104
Macaca mulatta	BET1	VGNC	VGNC:80799

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