2. Gene
  3. STX5 - syntaxin 5 Gene

STX5 - syntaxin 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SED5; STX5A

Gene ID: 6811 | Gene type: protein coding

About STX5

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,806,860-62,832,051 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 22.3), ovary (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in Autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

STX5 Products(3)

mRNA Protein Name
NM_001244666.3 NP_001231595.1 syntaxin-5 isoform 2
NM_001330294.2 NP_001317223.1 syntaxin-5 isoform 3
NM_003164.5 NP_003155.2 syntaxin-5 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SNAP receptor activity IDA
IDA: Inferred from direct assay
15215310 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi disassembly IDA
IDA: Inferred from direct assay
16081076 GOA
involved in early endosome to Golgi transport IMP
IMP: Inferred from mutant phenotype
17389686 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
21242315 GOA
involved in regulation of Golgi organization IDA
IDA: Inferred from direct assay
16081076 GOA
involved in retrograde transport, endosome to Golgi IDA
IDA: Inferred from direct assay
15215310 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
34711829 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
9464276 GOA
located in vesicle IDA
IDA: Inferred from direct assay
16081076 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX5 Protein Structure

Syntaxin

Syntaxin: Syntaxin (91 - 194)

SNARE

SNARE: SNARE domain (269 - 327)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

syntaxin-5

syntaxin 5A

STX5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STX5 Q13190 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
STX5 Q13190 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
STX5 Q13190 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
STX5 Q13190 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
STX5 Q13190 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra
STX5 Q13190 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
STX5 Q13190 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
STX5 Q13190 SEC22B Homo sapiens O75396
Anti Tag CoIP
35271311
Intra
STX5 Q13190 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
STX5 Q13190 DRC12 Homo sapiens Q494R4-2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 DRC12 Homo sapiens Q494R4-2
Validated Y2H
32296183
Intra
STX5 Q13190 DRC12 Homo sapiens Q494R4-2
Y2H Array
32296183
Intra
STX5 Q13190 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
STX5 Q13190 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
STX5 Q13190 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
STX5 Q13190 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
STX5 Q13190 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra
STX5 Q13190 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
STX5 Q13190 CRB3 Homo sapiens Q9BUF7-2
Validated Y2H
32296183
Intra
STX5 Q13190 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 MTUS1 Homo sapiens Q9ULD2-3
Validated Y2H
32296183
Intra
STX5 Q13190 MTUS1 Homo sapiens Q9ULD2-3
Y2H Array
32296183
Intra
STX5 Q13190 MTUS1 Homo sapiens Q9ULD2-3
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
STX5 Q13190 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
STX5 Q13190 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
STX5 Q13190 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
STX5 Q13190 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STING1 Homo sapiens Q86WV6
Validated Y2H
32296183
Intra
STX5 Q13190 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra
STX5 Q13190 COG4 Homo sapiens Q9H9E3
Pull Down
19536132
Intra
STX5 Q13190 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
STX5 Q13190 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
STX5 Q13190 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
STX5 Q13190 NAPB Homo sapiens Q9H115
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 NAPB Homo sapiens Q9H115
Y2H Array
32296183
Intra
STX5 Q13190 NAPB Homo sapiens Q9H115
Y2H Prey Pooling
25416956
Intra
STX5 Q13190 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
STX5 Q13190 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
STX5 Q13190 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 GOSR2 Homo sapiens O14653
Y2H Array
32296183
Intra
STX5 Q13190 GOSR2 Homo sapiens O14653
Anti Tag CoIP
35271311
Intra
STX5 Q13190 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 AARD Homo sapiens Q4LEZ3
Validated Y2H
32296183
Intra
STX5 Q13190 TACC1 Homo sapiens O75410
Y2H Array
25416956
Intra
STX5 Q13190 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
STX5 Q13190 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
STX5 Q13190 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
STX5 Q13190 STX8 Homo sapiens Q9UNK0
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STX8 Homo sapiens Q9UNK0
Y2H Array
32296183
Intra
STX5 Q13190 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
STX5 Q13190 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
STX5 Q13190 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
STX5 Q13190 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra
STX5 Q13190 NAPA Homo sapiens P54920
Anti Tag CoIP
35271311
Intra
STX5 Q13190 NAPA Homo sapiens P54920
Y2H Pooling
16189514
Intra
STX5 Q13190 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
STX5 Q13190 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
STX5 Q13190 CREB3L3 Homo sapiens Q68CJ9
Validated Y2H
32296183
Intra
STX5 Q13190 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra
STX5 Q13190 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia
Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN

Spondyloepiphyseal Dysplasia Nishimura Type
Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z

Charcot-Marie-Tooth Disease Axonal Type 2z

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z

Charcot-Marie-Tooth Neuropathy, Type 2z

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z

Charcot-Marie-Tooth Neuropathy Type 2z

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation

Charcot-Marie-Tooth Disease 2z

Charcot-Marie-Tooth Disease, Type 2z
Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia

SMC1

Smc

Smith Mccort Dysplasia

Smith-Mccort Dwarfism
Congenital Disorder Of Glycosylation, Type Iih

CDG2H

Congenital Disorder Of Glycosylation Type Iih

Cdg Iih

Cdgiih

Carbohydrate Deficient Glycoprotein Syndrome Type Iih

Congenital Disorder Of Glycosylation Type 2h

Cog8-Cdg

Cdg-Iih

Cdgiidh

Cdg Syndrome Type Iih

Congenital Disorder Of Glycosylation 2h

Glycosylation, Congenital Disorder Of, Type Iih
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

Cednik Syndrome

CEDNIK

Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro

Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome

Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma

Neurocutaneous Syndromes
Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome

DMC

Dmc Disease

Pseudo-Morquio Disease Type I

Dmc Syndrome
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13985 STX5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STX5 VGNC VGNC:46957
Macaca mulatta STX5 VGNC VGNC:78045
Felis catus STX5 VGNC VGNC:65815
Mus musculus STX5 MGD MGI:1928483
Rattus norvegicus STX5 RGD RGD:68426
Bos taurus STX5 VGNC VGNC:35441