2. Gene
  3. SRSF7 - serine and arginine rich splicing factor 7 Gene

SRSF7 - serine and arginine rich splicing factor 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 9G8; AAG3; SFRS7

Gene ID: 6432 | Gene type: protein coding

About SRSF7

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,743,599-38,751,494 (from NCBI)

This gene has 12 transcripts (splice variants), 232 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

SRSF7 Products(3)

mRNA Protein Name
NM_001031684.3 NP_001026854.1 serine/arginine-rich splicing factor 7 isoform 1
NM_001195446.2 NP_001182375.1 serine/arginine-rich splicing factor 7 isoform 2
NM_001363802.1 NP_001350731.1 serine/arginine-rich splicing factor 7 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10749975 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10749975 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA splicing IDA
IDA: Inferred from direct assay
8013463 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
15009664 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF7 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (13 - 77)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 7

SR splicing factor 7

SRSF7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SRSF7 Q16629 RBBP6 Homo sapiens Q7Z6E9
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 RBBP6 Homo sapiens Q7Z6E9
Anti Tag CoIP
18624398
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Array
31515488
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Prey Pooling
25416956
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
25416956
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Array
25416956
Intra
SRSF7 Q16629 RNPS1 Homo sapiens Q15287
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 NXF1 Homo sapiens Q9UBU9
Pull Down
17036044
Intra
SRSF7 Q16629 NXF1 Homo sapiens Q9UBU9
CoIP
15184380
Intra
SRSF7 Q16629 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 SRPK1 Homo sapiens Q96SB4
Protein Kinase Assay
23602568
Intra
SRSF7 Q16629 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 LUC7L Homo sapiens Q9NQ29-3
Validated Y2H
32296183
Intra
SRSF7 Q16629 PRPF38A Homo sapiens Q8NAV1
Validated Y2H
32296183
Intra
SRSF7 Q16629 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
SRSF7 Q16629 SDCBP Homo sapiens O00560
Y2H Array
25416956
Cross
SRSF7 Q16629 Srek1 Rattus norvegicus Q9JKL7
Pull Down
14559993
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary

Abpa

Allergic Bronchopulmonary Mycosis

Hinson-Pepys Disease

Pulmonary Aspergillus Disease

Allergic Aspergillosis

Aspergillosis Allergic Bronchopulmonary
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13798 SRSF7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SRSF7 VGNC VGNC:77822
Felis catus SRSF7 VGNC VGNC:81226
Canis familiaris SRSF7 VGNC VGNC:46821
Rattus norvegicus SRSF7 RGD RGD:1307425
Mus musculus SRSF7 MGD MGI:1926232
Bos taurus SRSF7 VGNC VGNC:35303