TRA2B - transformer 2 beta homolog Gene

Homo sapiens

Also known as SFRS10; SRFS10; TRAN2B; PPP1R156; TRA2-BETA; Htra2-beta

Gene ID: 6434 | Gene type: protein coding

About TRA2B

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,914,558-185,938,014 (from NCBI)

This gene has 15 transcripts (splice variants), 542 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 41.9), lymph node (RPKM 15.3) and 25 other tissues.

Summary

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TRA2B Products(2)

mRNA	Protein	Name
NM_001243879.2	NP_001230808.1	transformer-2 protein homolog beta isoform 2
NM_004593.3	NP_004584.1	transformer-2 protein homolog beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	10749975	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	10749975	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	12165565	GOA
enables pre-mRNA binding	IDA IDA: Inferred from direct assay	25689357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10749975	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10749975	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	25689357	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9546399	GOA
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	10749975	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	12165565	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25689357	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9546399	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10749975	GOA
part of spliceosomal complex	IMP IMP: Inferred from mutant phenotype	25689357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRA2B Protein Structure

RRM_1

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

transformer-2 protein homolog beta

TRA-2 beta

Recombinant TRA2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72056	TRA2B Protein, Human (Baculovirus, His-Myc)	P62995 (S2-Y288)	≥95%

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14962	TRA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRA2B	VGNC	VGNC:47759
Felis catus	TRA2B	VGNC	VGNC:66491
Bos taurus	TRA2B	VGNC	VGNC:36268
Macaca mulatta	TRA2B	VGNC	VGNC:78554
Rattus norvegicus	TRA2B	RGD	RGD:619886
Mus musculus	TRA2B	MGD	MGI:106016
Others	TRA2B	NCBI

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