2. Gene
  3. YTHDC1 - YTH domain containing 1 Gene

YTHDC1 - YTH domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as YT521; YT521-B

Gene ID: 91746 | Gene type: protein coding

About YTHDC1

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:68,310,387-68,350,090 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 22.7), ovary (RPKM 15.2) and 25 other tissues.

Summary

Enables N6-methyladenosine-containing RNA binding activity. Involved in mRNA export from nucleus; mRNA splice site selection; and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

YTHDC1 Products(3)

mRNA Protein Name
NM_001031732.4 NP_001026902.1 YTH domain-containing protein 1 isoform 1
NM_001330698.2 NP_001317627.1 YTH domain-containing protein 1 isoform 3
NM_133370.4 NP_588611.2 YTH domain-containing protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
25242552 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
20167602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15345239 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dosage compensation by inactivation of X chromosome IDA
IDA: Inferred from direct assay
27602518 GOA
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
28984244 GOA
involved in mRNA splice site recognition IDA
IDA: Inferred from direct assay
20167602 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
26876937 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
26876937 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20167602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDC1 Protein Structure

YTH

YTH: YT521-B-like domain (355 - 492)

  • 0
  • 200
  • 400
  • 600
  • 727 a.a.
Protein Preferred Names Protein Names

YTH domain-containing protein 1

putative splicing factor YT521

YTHDC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra YTHDC1 Q96MU7 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
32296183
Intra YTHDC1 Q96MU7 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra YTHDC1 Q96MU7 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 PHF19 Homo sapiens Q5T6S3
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 PHF19 Homo sapiens Q5T6S3
Y2H Array
32296183
Intra YTHDC1 Q96MU7 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra YTHDC1 Q96MU7 HNRNPK Homo sapiens P61978
Y2H Array
29892012
Intra YTHDC1 Q96MU7 ANKRD28 Homo sapiens O15084
Y2H Array
32296183
Intra YTHDC1 Q96MU7 ANKRD28 Homo sapiens O15084
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 SRPK1 Homo sapiens Q96SB4
BiFC
23602568
Intra YTHDC1 Q96MU7 SRPK2 Homo sapiens P78362
Anti Tag CoIP
23602568
Intra YTHDC1 Q96MU7 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra YTHDC1 Q96MU7 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra YTHDC1 Q96MU7 TRA2B Homo sapiens P62995
Y2H Array
32296183
Intra YTHDC1 Q96MU7 TRA2B Homo sapiens P62995
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
25416956
Intra YTHDC1 Q96MU7 DVL3 Homo sapiens Q92997
Validated Y2H
25416956
Intra YTHDC1 Q96MU7 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 DVL3 Homo sapiens Q92997
Y2H Array
25416956
Intra YTHDC1 Q96MU7 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
Intra YTHDC1 Q96MU7 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
32296183
Intra YTHDC1 Q96MU7 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra YTHDC1 Q96MU7 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
Intra YTHDC1 Q96MU7 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 CLK2 Homo sapiens P49760
Y2H Array
32296183
Intra YTHDC1 Q96MU7 CLK2 Homo sapiens P49760
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra YTHDC1 Q96MU7 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra YTHDC1 Q96MU7 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
25416956
Intra YTHDC1 Q96MU7 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra YTHDC1 Q96MU7 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatoblastoma
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-158974 YTHDC1-IN-1 99.44% Unkown
HY-164607 YL-5092 99.83% Unkown
HY-RS15935 YTHDC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-168610 YTH-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YTHDC1 MGD MGI:2443713
Rattus norvegicus YTHDC1 RGD RGD:621706
Canis familiaris YTHDC1 VGNC VGNC:48503
Felis catus YTHDC1 VGNC VGNC:67150
Macaca mulatta YTHDC1 VGNC VGNC:79860
Bos taurus YTHDC1 VGNC VGNC:37039