2. Gene
  3. STK4 - serine/threonine kinase 4 Gene

STK4 - serine/threonine kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KRS2; MST1; YSK3

Gene ID: 6789 | Gene type: protein coding

About STK4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,966,512-45,080,021 (from NCBI)

This gene has 17 transcripts (splice variants), 130 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with Apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

STK4 Products(2)

mRNA Protein Name
NM_001352385.2 NP_001339314.1 serine/threonine-protein kinase 4 isoform 2
NM_006282.5 NP_006273.1 serine/threonine-protein kinase 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
8566796 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16751106 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
8702870 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
8566796 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14729613 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11805089 GOA
enables protein kinase activity IGI
IGI: Inferred from genetic interaction
19962960 GOA
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
9545236 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8566796 GOA
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
21212262 GOA
acts upstream of or within cell morphogenesis IDA
IDA: Inferred from direct assay
11805089 GOA
involved in hippo signaling IDA
IDA: Inferred from direct assay
20412773 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
8566796 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20412773 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
16751106 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
15109305 GOA
acts upstream of or within positive regulation of hippo signaling IDA
IDA: Inferred from direct assay
22292086 GOA
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
11805089 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
16751106 GOA
involved in protein import into nucleus IGI
IGI: Inferred from genetic interaction
16751106 GOA
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
11805089 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8566796 GOA
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
19962960 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
35429439 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17932490 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17932490 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
19962960 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (31 - 281)

Mst1_SARAH

Mst1_SARAH: C terminal SARAH domain of Mst1 (432 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 4

STE20-like kinase MST1

STK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
BioID
24255178
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
24366813
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
20920251
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
16930133
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
20562859
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
24981860
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
Anti Tag CoIP
24255178
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
23455922
Intra
STK4 Q13043 SAV1 Homo sapiens Q9H4B6
TAP
23386615
Intra
STK4 Q13043 SLMAP Homo sapiens Q14BN4
BioID
24255178
Intra
STK4 Q13043 SLMAP Homo sapiens Q14BN4
Anti Tag CoIP
35271311
Intra
STK4 Q13043 SLMAP Homo sapiens Q14BN4
Anti Tag CoIP
24366813
Cross
STK4 Q13043 Stk38 Mus musculus Q91VJ4
Protein Kinase Assay
21730291
Intra
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
35271311
Intra
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
20920251
Intra
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
TAP
23455922
Intra
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
BioID
24255178
Intra
STK4 Q13043 RASSF3 Homo sapiens Q86WH2
Anti Tag CoIP
24366813
Intra
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
20562859
Intra
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
TAP
23455922
Intra
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Y2H
20920251
Intra
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
35271311
Intra
STK4 Q13043 RASSF4 Homo sapiens Q9H2L5
Anti Tag CoIP
24366813
Intra
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
24366813
Intra
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
35271311
Intra
STK4 Q13043 RASSF6 Homo sapiens Q6ZTQ3
Anti Tag CoIP
20920251
Intra
STK4 Q13043 AKT1 Homo sapiens P31749
Anti Bait CoIP
17932490
Intra
STK4 Q13043 AKT1 Homo sapiens P31749
Anti Tag CoIP
17932490
Intra
STK4 Q13043 AKT1 Homo sapiens P31749
IF
17932490
Intra
STK4 Q13043 PRDX1 Homo sapiens Q06830
TAP
23386615
Intra
STK4 Q13043 PRDX1 Homo sapiens Q06830
Anti Tag CoIP
23386615
Intra
STK4 Q13043 PRDX1 Homo sapiens Q06830
Protein Kinase Assay
23386615
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
TAP
24981860
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
20562859
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
TAP
23455922
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
BioID
24255178
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
24366813
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
35271311
Intra
STK4 Q13043 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
CoIP
15109305
Intra
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Y2H
14729613
Intra
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Anti Tag CoIP
20920251
Intra
STK4 Q13043 RASSF1 Homo sapiens Q9NS23-2
Y2H
20920251
Cross
STK4 Q13043 Prdx1 Mus musculus P35700
Anti Tag CoIP
21516123
Cross
STK4 Q13043 Prdx1 Mus musculus P35700
Protein Kinase Assay
21516123
Intra
STK4 Q13043 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
STK4 Q13043 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
STK4 Q13043 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Intra
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
24255178
Intra
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
Protein Kinase Assay
21516123
Intra
STK4 Q13043 MOB1A Homo sapiens Q9H8S9
TAP
23386615
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
35271311
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
20920251
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
23386615
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
24981860
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Y2H
20920251
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
20562859
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
24255178
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
TAP
23455922
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
BioID
24255178
Intra
STK4 Q13043 RASSF2 Homo sapiens P50749
Anti Tag CoIP
24366813
Intra
STK4 Q13043 RASSF5 Homo sapiens Q8WWW0-3
Y2H
20920251
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
24255178
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
23455922
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
BioID
24255178
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
23386615
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
35271311
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
24366813
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
TAP
24981860
Intra
STK4 Q13043 STK3 Homo sapiens Q13188
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK4 Proteins

Cat. No. Product Name Accession Purity
HY-P74742 MST1/STK4 Protein, Human (sf9, His) Q13043 (E2-F487) ≥95%

STK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81903 MSP Antibody (YA1648) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations

Combined Immunodeficiency Due To Stk4 Deficiency

TIIAC

Stk4 Deficiency

Mst1 Deficiency

T-Cell Immunodeficiency, Recurrent Infections, Autoimmunity, And Cardiac Malformations

Cid Due To Stk4 Deficiency
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity

IMD63

Il2rb Deficiency

Cd122 Deficiency

Immunodeficiency 63

Interleukin 2 Receptor, Beta, Deficiency Of

Deficiency Of Interleukin 2 Receptor Beta
Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Coronin-1a Deficiency
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132969 SBP-3264 98.63% Unkown
HY-RS13941 STK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STK4 VGNC VGNC:81228
Rattus norvegicus STK4 RGD RGD:1312035
Mus musculus STK4 MGD MGI:1929004
Canis familiaris STK4 VGNC VGNC:46922
Bos taurus STK4 VGNC VGNC:35401
Macaca mulatta STK4 VGNC VGNC:81588
Others STK4 NCBI