RASSF2 - Ras association domain family member 2 Gene

Homo sapiens

Also known as CENP-34; RASFADIN

Gene ID: 9770 | Gene type: protein coding

About RASSF2

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,780,023-4,823,608 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 5 paralogues. Broad expression in brain (RPKM 57.7), bone marrow (RPKM 38.0) and 16 other tissues.

Summary

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

RASSF2 Products(2)

mRNA	Protein	Name
NM_014737.3	NP_055552.1	ras association domain-containing protein 2
NM_170774.2	NP_739580.1	ras association domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12732644	GOA
enables protein kinase activity	IGI IGI: Inferred from genetic interaction	19962960	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	19962960	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19525978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19525978	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20813266	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19525978	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19962960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF2 Protein Structure

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

ras association domain-containing protein 2

Ras association (RalGDS/AF-6) domain family 2

RASSF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RASSF2	P50749	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RASSF2	P50749	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RASSF2	P50749	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RASSF2	P50749	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	RASSF2	P50749	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	RASSF2	P50749	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	RASSF2	P50749	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	RASSF2	P50749	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	RASSF2	P50749	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	RASSF2	P50749	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	RASSF2	P50749	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	RASSF2	P50749	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	RASSF2	P50749	STK4	Homo sapiens	Q13043	Anti Tag CoIP	33961781
Intra	RASSF2	P50749	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178
Intra	RASSF2	P50749	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	RASSF2	P50749	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	RASSF2	P50749	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	RASSF2	P50749	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	RASSF2	P50749	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	RASSF2	P50749	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	RASSF2	P50749	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	RASSF2	P50749	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	RASSF2	P50749	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	BioID	24255178
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	Anti Tag CoIP	33961781
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	Anti Tag CoIP	28514442
Intra	RASSF2	P50749	STK3	Homo sapiens	Q13188	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11702	RASSF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RASSF2	VGNC	VGNC:45380
Macaca mulatta	RASSF2	VGNC	VGNC:76674
Mus musculus	RASSF2	MGD	MGI:2442060
Felis catus	RASSF2	VGNC	VGNC:69253
Rattus norvegicus	RASSF2	RGD	RGD:1305551
Bos taurus	RASSF2	VGNC	VGNC:33758

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