BST2 - bone marrow stromal cell antigen 2 Gene

Homo sapiens

Also known as CD317; HM1.24; TETHERIN

Gene ID: 684 | Gene type: protein coding

About BST2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,402,939-17,405,630 (from NCBI)

This gene has 3 transcripts (splice variants) and 83 orthologues. Broad expression in ovary (RPKM 235.4), adrenal (RPKM 135.4) and 22 other tissues.

Summary

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

BST2 Products(1)

mRNA	Protein	Name
NM_004335.4	NP_004326.1	bone marrow stromal antigen 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19879838	GOA
enables metalloendopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	22065321	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19179289	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20399176	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	20399176	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	19036818	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	22065321	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	22065321	GOA
involved in negative regulation of intracellular transport of viral material	IDA IDA: Inferred from direct assay	19036818	GOA
involved in negative regulation of plasmacytoid dendritic cell cytokine production	IDA IDA: Inferred from direct assay	19564354	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	20943977	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19036818	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IMP IMP: Inferred from mutant phenotype	22072966	GOA
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	22065321	GOA
located in multivesicular body	IMP IMP: Inferred from mutant phenotype	22072966	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19036818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone marrow stromal antigen 2

BST-2

BST2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	BST2	Q10589	Ap1m1	Mus musculus	P35585	GMS	24843023
Cross	BST2	Q10589	GP	Zaire ebolavirus	A9QPL9	Anti Bait CoIP	19179289
Cross	BST2	Q10589	GP	Zaire ebolavirus	A9QPL9	Anti Tag CoIP	19179289
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	X-Ray Diffraction	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	TEM	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Light Scattering	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	X-Ray Diffraction	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Solution Sedimentation	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	SLCA	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	GMS	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Comigration in SDS	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Comigration in Gel	19879838
Intra	BST2	Q10589	vpu	Human immunodeficiency virus	P69699	Solution NMR	22072710
Intra	BST2	Q10589	vpu	Human immunodeficiency virus	P69699	Solid State NMR	22072710

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BST2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7673	BST2 Protein, Human (HEK293, His)	Q10589 (N49-S161)	≥95%

Related Diseases

Diseases

Alias

Stomatitis

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Colorado Tick Fever

Mountain Tick Fever	Tick Fever, American Mountain
American Mountain Fever	Colorado Tick Encephalitis
Colorado Tick-Borne Disease	Mountain Fever
American Mountain Tick Fever	Colorado Tick-Borne Fever
Colorado Tick Fever Virus	Non-Exanthematous Tick Fever

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Lassa Fever

Lf	Lassa Hemorrhagic Fever
Lf - [Lassa Fever]

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125900	Neocarzilin A		95.82%	Unkown
HY-RS01649	BST2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BST2	MGD	MGI:1916800
Canis familiaris	BST2	VGNC	VGNC:38542
Macaca mulatta	BST2	VGNC	VGNC:70286
Rattus norvegicus	BST2	RGD	RGD:727849
Felis catus	BST2	VGNC	VGNC:102008
Macaca fascicularis	BST2	NCBI	NCBI:102128665
Others	BST2	NCBI

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