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  2. TFAP4 - transcription factor AP-4 Gene

TFAP4 - transcription factor AP-4 Gene

Homo sapiens

Also known as AP-4; bHLHc41

Gene ID: 7023 | Gene type: protein coding

About TFAP4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,257,186-4,273,023 (from NCBI)

This gene has 7 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues.

Summary

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

TFAP4 Products(1)

mRNA Protein Name
NM_003223.3 NP_003214.1 transcription factor AP-4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
9931457 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
2833704 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
2833704 GOA
enables E-box binding IDA
IDA: Inferred from direct assay
7933101 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
16540471 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16924111 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
2123466 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
2123466 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
2833704 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
7933101 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFAP4 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (49 - 100)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
Protein Preferred Names Protein Names

transcription factor AP-4

activating enhancer-binding protein 4

TFAP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TFAP4 Q01664 PTPN3 Homo sapiens P26045 32296183
Intra
TFAP4 Q01664 PTPN3 Homo sapiens P26045 32296183
Intra
TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0 32296183
Intra
TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0 32296183
Intra
TFAP4 Q01664 SFMBT2 Homo sapiens Q5VUG0 32296183
Intra
TFAP4 Q01664 NDUFB7 Homo sapiens P17568 32296183
Intra
TFAP4 Q01664 NDUFB7 Homo sapiens P17568 32296183
Intra
TFAP4 Q01664 KLK6 Homo sapiens Q92876 32814053
Intra
TFAP4 Q01664 KLK6 Homo sapiens Q92876 32814053
Intra
TFAP4 Q01664 KLK6 Homo sapiens Q92876 32814053
Intra
TFAP4 Q01664 VMAC Homo sapiens Q2NL98 32296183
Intra
TFAP4 Q01664 VMAC Homo sapiens Q2NL98 32296183
Intra
TFAP4 Q01664 VMAC Homo sapiens Q2NL98 32296183
Intra
TFAP4 Q01664 MCRS1 Homo sapiens Q96EZ8 32296183
Intra
TFAP4 Q01664 TRAF1 Homo sapiens Q13077 32296183
Intra
TFAP4 Q01664 TRAF1 Homo sapiens Q13077 32296183
Intra
TFAP4 Q01664 TRAF1 Homo sapiens Q13077 32296183
Intra
TFAP4 Q01664 TRAF1 Homo sapiens Q13077 25416956
Intra
TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
TFAP4 Q01664 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26 32296183
Intra
TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26 25416956
Intra
TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26 32296183
Intra
TFAP4 Q01664 EXOSC8 Homo sapiens Q96B26 32296183
Intra
TFAP4 Q01664 GOLGA2 Homo sapiens Q08379 25416956
Intra
TFAP4 Q01664 GOLGA2 Homo sapiens Q08379 32296183
Intra
TFAP4 Q01664 GOLGA2 Homo sapiens Q08379 32296183
Intra
TFAP4 Q01664 GOLGA2 Homo sapiens Q08379 32296183
Intra
TFAP4 Q01664 INCA1 Homo sapiens Q0VD86 32296183
Intra
TFAP4 Q01664 INCA1 Homo sapiens Q0VD86 32296183
Intra
TFAP4 Q01664 INCA1 Homo sapiens Q0VD86 32296183
Intra
TFAP4 Q01664 GEM Homo sapiens P55040 16924111
Intra
TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24 32296183
Intra
TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24 32296183
Intra
TFAP4 Q01664 TEKT4 Homo sapiens Q8WW24 32296183
Intra
TFAP4 Q01664 AJUBA Homo sapiens Q96IF1 32296183
Intra
TFAP4 Q01664 AJUBA Homo sapiens Q96IF1 32296183
Intra
TFAP4 Q01664 AJUBA Homo sapiens Q96IF1 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus TFAP4 MGD MGI:103239
Bos taurus TFAP4 VGNC VGNC:35781
Rattus norvegicus TFAP4 RGD RGD:1308357
Felis catus TFAP4 VGNC VGNC:107823
Macaca mulatta TFAP4 VGNC VGNC:104759
Canis familiaris TFAP4 VGNC VGNC:47287