2. Gene
  3. TFAP4 - transcription factor AP-4 Gene

TFAP4 - transcription factor AP-4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AP-4; bHLHc41

Gene ID: 7023 | Gene type: protein coding

About TFAP4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,257,186-4,273,023 (from NCBI)

This gene has 7 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues.

Summary

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

TFAP4 Products(1)

mRNA Protein Name
NM_003223.3 NP_003214.1 transcription factor AP-4

TFAP4 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (49 - 100)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
Protein Preferred Names Protein Names

transcription factor AP-4

activating enhancer-binding protein 4

Related Diseases

Diseases Alias
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14412 TFAP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TFAP4 MGD MGI:103239
Bos taurus TFAP4 VGNC VGNC:35781
Rattus norvegicus TFAP4 RGD RGD:1308357
Felis catus TFAP4 VGNC VGNC:107823
Macaca mulatta TFAP4 VGNC VGNC:104759
Canis familiaris TFAP4 VGNC VGNC:47287