2. Gene
  3. TM4SF4 - transmembrane 4 L six family member 4 Gene

TM4SF4 - transmembrane 4 L six family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILTMP; il-TMP

Gene ID: 7104 | Gene type: protein coding

About TM4SF4

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,474,697-149,503,394 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF4 Products(1)

mRNA Protein Name
NM_004617.4 NP_004608.1 transmembrane 4 L6 family member 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM4SF4 Protein Structure

L6_membrane

L6_membrane: L6 membrane protein (1 - 192)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

transmembrane 4 L6 family member 4

intestinal and liver (il) tetraspan membrane protein

TM4SF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TM4SF4 P48230 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra TM4SF4 P48230 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra TM4SF4 P48230 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra TM4SF4 P48230 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra TM4SF4 P48230 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra TM4SF4 P48230 GJB4 Homo sapiens Q9NTQ9
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GJB4 Homo sapiens Q9NTQ9
Y2H Array
32296183
Intra TM4SF4 P48230 GJB4 Homo sapiens Q9NTQ9
Validated Y2H
32296183
Intra TM4SF4 P48230 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra TM4SF4 P48230 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GPR101 Homo sapiens Q96P66
Validated Y2H
32296183
Intra TM4SF4 P48230 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra TM4SF4 P48230 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra TM4SF4 P48230 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra TM4SF4 P48230 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra TM4SF4 P48230 TBXA2R Homo sapiens Q0VAB0
Validated Y2H
32296183
Intra TM4SF4 P48230 TBXA2R Homo sapiens Q0VAB0
Y2H Array
32296183
Intra TM4SF4 P48230 TBXA2R Homo sapiens Q0VAB0
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 CMTM2 Homo sapiens Q8TAZ6
Y2H Array
32296183
Intra TM4SF4 P48230 CMTM2 Homo sapiens Q8TAZ6
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 CMTM2 Homo sapiens Q8TAZ6
Validated Y2H
32296183
Intra TM4SF4 P48230 APH1B Homo sapiens Q8WW43
Validated Y2H
32296183
Intra TM4SF4 P48230 APH1B Homo sapiens Q8WW43
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 APH1B Homo sapiens Q8WW43
Y2H Array
32296183
Intra TM4SF4 P48230 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra TM4SF4 P48230 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra TM4SF4 P48230 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra TM4SF4 P48230 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra TM4SF4 P48230 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra TM4SF4 P48230 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra TM4SF4 P48230 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra TM4SF4 P48230 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra TM4SF4 P48230 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra TM4SF4 P48230 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra TM4SF4 P48230 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra TM4SF4 P48230 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra TM4SF4 P48230 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra TM4SF4 P48230 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra TM4SF4 P48230 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cutis Laxa, Autosomal Dominant 2

ADCL2

Autosomal Dominant Cutis Laxa 2

Cutis Laxa, Autosomal Dominant, 2

Cutis Laxa, Autosomal Dominant, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14609 TM4SF4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TM4SF4 VGNC VGNC:102855
Macaca mulatta TM4SF4 VGNC VGNC:78564
Mus musculus TM4SF4 MGD MGI:2385173
Canis familiaris TM4SF4 VGNC VGNC:47409
Rattus norvegicus TM4SF4 RGD RGD:621784
Bos taurus TM4SF4 VGNC VGNC:35906