TP53BP2 - tumor protein p53 binding protein 2 Gene

Homo sapiens

Also known as BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

Gene ID: 7159 | Gene type: protein coding

About TP53BP2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,779,893-223,845,947 (from NCBI)

This gene has 13 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), brain (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates Apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TP53BP2 Products(2)

mRNA	Protein	Name
NM_001031685.3	NP_001026855.2	apoptosis-stimulating of p53 protein 2 isoform 1
NM_005426.3	NP_005417.1	apoptosis-stimulating of p53 protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	10498867	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18448430	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	14985081	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8875926	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	25963096	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	11684014	GOA
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	14985081	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10646860	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19377511	GOA
colocalizes with perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10646860	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14985081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53BP2 Protein Structure

Ank_2

SH3_1

0
200
400
600
800
1000
1134 a.a.

Protein Preferred Names

Protein Names

apoptosis-stimulating of p53 protein 2

BCL2-binding protein

Related Diseases

Diseases

Alias

Chromosome 1q41-Q42 Deletion Syndrome

1q41-Q42 Microdeletion Syndrome	1q41q42 Microdeletion Syndrome
Holoprosencephaly 10, Included	Hpe10, Included
1q41-Q42 Deletion Syndrome	Deletion 1q41-Q42
Monosomy 1q41-Q42	Del(1)(Q41q42)
Monosomy 1q41q42	Chromosome Deletion Syndrome 1q41-Q42
Holoprosencephaly 10

Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14916	TP53BP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TP53BP2	VGNC	VGNC:47721
Felis catus	TP53BP2	VGNC	VGNC:66462
Mus musculus	TP53BP2	MGD	MGI:2138319
Bos taurus	TP53BP2	VGNC	VGNC:36233
Rattus norvegicus	TP53BP2	RGD	RGD:1305461
Macaca mulatta	TP53BP2	VGNC	VGNC:78629

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