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  3. TP53BP2 - tumor protein p53 binding protein 2 Gene

TP53BP2 - tumor protein p53 binding protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

Gene ID: 7159 | Gene type: protein coding

About TP53BP2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,779,893-223,845,947 (from NCBI)

This gene has 13 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), brain (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates Apoptosis and cell growth through interactions with Other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TP53BP2 Products(2)

mRNA Protein Name
NM_001031685.3 NP_001026855.2 apoptosis-stimulating of p53 protein 2 isoform 1
NM_005426.3 NP_005417.1 apoptosis-stimulating of p53 protein 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
10498867 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18448430 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
14985081 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8875926 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
25963096 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
11684014 GOA
involved in positive regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
14985081 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10646860 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19377511 GOA
colocalizes with perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10646860 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14985081 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53BP2 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (943 - 1024)

SH3_1

SH3_1: SH3 domain (1070 - 1116)

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  • 1134 a.a.
Protein Preferred Names Protein Names

apoptosis-stimulating of p53 protein 2

BCL2-binding protein

TP53BP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TP53BP2 Q13625 APC2 Homo sapiens O95996
Y2H
10646860
Intra
TP53BP2 Q13625 ITCH Homo sapiens Q96J02
Anti Bait CoIP
25436413
Intra
TP53BP2 Q13625 RAN Homo sapiens P62826
Far-WB
24855949
Intra
TP53BP2 Q13625 RAN Homo sapiens P62826
Pull Down
24855949
Intra
TP53BP2 Q13625 BCL2L1 Homo sapiens Q07817-1
Peptide Array
18719108
Intra
TP53BP2 Q13625 BCL2L1 Homo sapiens Q07817-1
SPR
18719108
Intra
TP53BP2 Q13625 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
TP53BP2 Q13625 PPP1CC Homo sapiens P36873
Anti Tag CoIP
21998301
Intra
TP53BP2 Q13625 PPP1CC Homo sapiens P36873
Anti Tag CoIP
24366813
Intra
TP53BP2 Q13625 PPP1CC Homo sapiens P36873
Anti Bait CoIP
21998301
Intra
TP53BP2 Q13625 PPP1CA Homo sapiens P62136
Anti Bait CoIP
21998301
Intra
TP53BP2 Q13625 PPP1CA Homo sapiens P62136
Y2H
22321011
Intra
TP53BP2 Q13625 PPP1CA Homo sapiens P62136
Anti Tag CoIP
21998301
Intra
TP53BP2 Q13625 PPP1CA Homo sapiens P62136
Anti Tag CoIP
24366813
Intra
TP53BP2 Q13625 PPP1CA Homo sapiens P62136
Y2H
15231748
Intra
TP53BP2 Q13625 TP53 Homo sapiens P04637
Anti Bait CoIP
21513714
Intra
TP53BP2 Q13625 TP53 Homo sapiens P04637
Y2H Array
31515488
Intra
TP53BP2 Q13625 TP53 Homo sapiens P04637
Y2H Array
25502805
Intra
TP53BP2 Q13625 TP53 Homo sapiens P04637
Pull Down
14985081
Intra
TP53BP2 Q13625 EP300 Homo sapiens Q09472
Anti Bait CoIP
21513714
Intra
TP53BP2 Q13625 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
25344754
Intra
TP53BP2 Q13625 BCL2L2 Homo sapiens Q92843
Peptide Array
18448430
Intra
TP53BP2 Q13625 BCL2L2 Homo sapiens Q92843
Peptide Array
18719108
Intra
TP53BP2 Q13625 BCL2L2 Homo sapiens Q92843
SPR
18719108
Intra
TP53BP2 Q13625 RELA Homo sapiens Q04206
Peptide Array
18448430
Intra
TP53BP2 Q13625 RELA Homo sapiens Q04206
Fluorescence
18448430
Intra
TP53BP2 Q13625 APP Homo sapiens P05067
Y2H
11278849
Intra
TP53BP2 Q13625 BCL2 Homo sapiens P10415
Peptide Array
18719108
Intra
TP53BP2 Q13625 BCL2 Homo sapiens P10415
SPR
18719108
Intra
TP53BP2 Q13625 BCL2 Homo sapiens P10415
Fluorescence
18719108
Intra
TP53BP2 Q13625 BCL2 Homo sapiens P10415
PLA
18719108
Cross
TP53BP2 Q13625 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
Anti Tag CoIP
14985081
Cross
TP53BP2 Q13625 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
Pull Down
14985081
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 1q41-Q42 Deletion Syndrome

1q41-Q42 Microdeletion Syndrome

1q41q42 Microdeletion Syndrome

Holoprosencephaly 10, Included

Hpe10, Included

1q41-Q42 Deletion Syndrome

Deletion 1q41-Q42

Monosomy 1q41-Q42

Del(1)(Q41q42)

Monosomy 1q41q42

Chromosome Deletion Syndrome 1q41-Q42

Holoprosencephaly 10
Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14916 TP53BP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TP53BP2 VGNC VGNC:47721
Felis catus TP53BP2 VGNC VGNC:66462
Mus musculus TP53BP2 MGD MGI:2138319
Bos taurus TP53BP2 VGNC VGNC:36233
Rattus norvegicus TP53BP2 RGD RGD:1305461
Macaca mulatta TP53BP2 VGNC VGNC:78629