OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

Homo sapiens

Also known as OTB2; OTU2; C14orf137

Gene ID: 78990 | Gene type: protein coding

About OTUB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,026,340-94,048,930 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues.

Summary

This gene encodes one of several deubiquitylating Enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling Enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

OTUB2 Products(1)

mRNA	Protein	Name
NM_023112.4	NP_075601.1	ubiquitin thioesterase OTUB2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	18954305	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	15258613	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	18954305	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	18954305	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	15258613	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUB2 Protein Structure

Peptidase_C65

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

ubiquitin thioesterase OTUB2

OTU domain, ubiquitin aldehyde binding 2

OTUB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTUB2	Q96DC9	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	OTUB2	Q96DC9	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	OTUB2	Q96DC9	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	OTUB2	Q96DC9	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	OTUB2	Q96DC9	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	PMEPA1	Homo sapiens	Q969W9-2	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	PMEPA1	Homo sapiens	Q969W9-2	Y2H Array	32296183
Intra	OTUB2	Q96DC9	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	OTUB2	Q96DC9	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	OTUB2	Q96DC9	MID1	Homo sapiens	O15344	Y2H Prey Pooling	25416956
Intra	OTUB2	Q96DC9	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	OTUB2	Q96DC9	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	OTUB2	Q96DC9	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	SPART	Homo sapiens	Q8N0X7	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	SPART	Homo sapiens	Q8N0X7	Y2H Array	32296183
Intra	OTUB2	Q96DC9	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	25416956
Intra	OTUB2	Q96DC9	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	ARRDC3	Homo sapiens	Q96B67	Y2H Array	25416956
Intra	OTUB2	Q96DC9	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	OTUB2	Q96DC9	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	OTUB2	Q96DC9	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
Intra	OTUB2	Q96DC9	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	OTUB2	Q96DC9	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	OTUB2	Q96DC9	CPSF6	Homo sapiens	Q16630	Validated Y2H	25416956
Intra	OTUB2	Q96DC9	CPSF6	Homo sapiens	Q16630	Y2H Prey Pooling	25416956
Intra	OTUB2	Q96DC9	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
Intra	OTUB2	Q96DC9	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
Intra	OTUB2	Q96DC9	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	OTUB2	Q96DC9	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	OTUB2	Q96DC9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	OTUB2	Q96DC9	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	OTUB2	Q96DC9	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	OTUB2	Q96DC9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	OTUB2	Q96DC9	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	OTUB2	Q96DC9	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	OTUB2	Q96DC9	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	OTUB2	Q96DC9	FAM168A	Homo sapiens	Q92567	Y2H Array	31515488
Intra	OTUB2	Q96DC9	FAM168A	Homo sapiens	Q92567	Y2H Prey Pooling	25416956
Intra	OTUB2	Q96DC9	FAM168A	Homo sapiens	Q92567	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OTUB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71182	OTUB2 Protein, Human (GST)	Q96DC9-1 (M1-H234)	≥95%
HY-P77118	OTUB2 Protein, Human (His)	Q96DC9-1 (M1-H234)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149482	LN5P45	Inhibitor	99.05%	Unkown
HY-160768	OTUB2-IN-1	Inhibitor	98.79%	Unkown
HY-RS09870	OTUB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OTUB2	VGNC	VGNC:32492
Mus musculus	OTUB2	MGD	MGI:1915399
Macaca mulatta	OTUB2	VGNC	VGNC:75656
Rattus norvegicus	OTUB2	RGD	RGD:1306688
Felis catus	OTUB2	VGNC	VGNC:80887
Canis familiaris	OTUB2	VGNC	VGNC:44183
Others	OTUB2	NCBI

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