TMEM109 - transmembrane protein 109 Gene

Homo sapiens

Gene ID: 79073 | Gene type: protein coding

About TMEM109

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,914,158-60,923,443 (from NCBI)

This gene has 3 transcripts (splice variants) and 118 orthologues. Ubiquitous expression in fat (RPKM 44.7), lung (RPKM 42.9) and 25 other tissues.

Summary

Predicted to enable voltage-gated ion channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

TMEM109 Products(1)

mRNA	Protein	Name
NM_024092.3	NP_076997.1	transmembrane protein 109 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	23542032	GOA
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	23542032	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM109 Protein Structure

BRI3BP

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 109

mg23

TMEM109 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM109	Q9BVC6	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	TMEM109	Q9BVC6	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	TMEM109	Q9BVC6	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	TMEM109	Q9BVC6	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM109	Q9BVC6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TMEM109	Q9BVC6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14650	TMEM109 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM109	VGNC	VGNC:66259
Macaca mulatta	TMEM109	VGNC	VGNC:79740
Canis familiaris	TMEM109	VGNC	VGNC:47450
Rattus norvegicus	TMEM109	RGD	RGD:1359538
Mus musculus	TMEM109	MGD	MGI:1915789
Bos taurus	TMEM109	VGNC	VGNC:35949

Name
Email *

	Sorry, but the email address you supplied was invalid.