GSDMD - gasdermin D Gene

Homo sapiens

Also known as DF5L; DFNA5L; FKSG10; GSDMDC1

Gene ID: 79792 | Gene type: protein coding

About GSDMD

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,553,387-143,563,062 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 187 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 35.6), duodenum (RPKM 18.8) and 24 other tissues.

Summary

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

GSDMD Products(2)

mRNA	Protein	Name
NM_001166237.1	NP_001159709.1	gasdermin-D
NM_024736.7	NP_079012.3	gasdermin-D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	27281216	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	36227980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables wide pore channel activity	IDA IDA: Inferred from direct assay	32109412	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	32109412	GOA
involved in positive regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	33883744	GOA
involved in positive regulation of interleukin-18 production	IDA IDA: Inferred from direct assay	33883744	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	33883744	GOA
involved in protein secretion	IDA IDA: Inferred from direct assay	33883744	GOA
involved in pyroptotic cell death	IDA IDA: Inferred from direct assay	32109412	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	28392147	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in membrane	IDA IDA: Inferred from direct assay	32109412	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32109412	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	33883744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMD Protein Structure

Gasdermin

0
100
200
300
400
484 a.a.

Protein Preferred Names

Protein Names

gasdermin-D

gasdermin domain containing 1

GSDMD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Validated Y2H	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Array	32296183
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	34296442
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Pull Down	34296442
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Validated Y2H	32296183
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Pull Down	34296442
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Protease Assay	34296442
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GSDMD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81230	GSDMD Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human
HY-P83706	GSDMD Antibody (YA3443)	WB	Human

Related Diseases

Diseases

Alias

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Bacterial Sepsis

Salmonellosis

Salmonella Infections

Salmonella Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0240	Disulfiram		99.78%	Unkown
HY-B0240R	Disulfiram (Standard)		/	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100381	Nigericin sodium salt		99.37%	Unkown
HY-13453	BAY 11-7082		99.98%	Unkown
HY-127019	Nigericin		99.43%	Unkown
HY-111674	LDC7559	Inhibitor	99.51%	Unkown
HY-N0816	Polyphyllin VI		98.41%	Unkown
HY-111675	Ac-FLTD-CMK	Inhibitor	99.53%	Unkown
HY-152670	JC2-11	Inhibitor	98.02%	Unkown
HY-171007	IRF1-IN-2		99.83%	Unkown
HY-RS05857	GSDMD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-130480	Fructose-arginine	Inhibitor	/	Unkown
HY-156374	D359-0396	Inhibitor	/	Unkown
HY-161332	Antitumor agent-143		/	Unkown
HY-161727	P2Y14R antagonist 1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSDMD	MGD	MGI:1916396
Macaca mulatta	GSDMD	VGNC	VGNC:73232
Rattus norvegicus	GSDMD	RGD	RGD:1307261
Canis familiaris	GSDMD	VGNC	VGNC:41526
Felis catus	GSDMD	VGNC	VGNC:62726
Bos taurus	GSDMD	VGNC	VGNC:29675

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