2. Gene
  3. ARHGEF5 - Rho guanine nucleotide exchange factor 5 Gene

ARHGEF5 - Rho guanine nucleotide exchange factor 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P60; TIM; GEF5; TIM1

Gene ID: 7984 | Gene type: protein coding

About ARHGEF5

Cytogenetic location: 7q35 Genomic coordinates (GRCh38): 7:144,355,402-144,380,632 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 198 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 23.4), skin (RPKM 15.6) and 23 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

ARHGEF5 Products(1)

mRNA Protein Name
NM_005435.4 NP_005426.2 rho guanine nucleotide exchange factor 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
15601624 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12006984 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15601624 GOA
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
15601624 GOA
involved in positive regulation of protein import IMP
IMP: Inferred from mutant phenotype
15601624 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
15601624 GOA
NOT involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
15601624 GOA
acts upstream of or within regulation of GTPase activity IDA
IDA: Inferred from direct assay
21525037 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
14662653 GOA
involved in regulation of cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15601624 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell periphery IDA
IDA: Inferred from direct assay
25911094 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
14662653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14662653 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF5 Protein Structure

ARHGEF5_35

ARHGEF5_35: Rho guanine nucleotide exchange factor 5/35 (1 - 478)

RhoGEF

RhoGEF: RhoGEF domain (1180 - 1356)

SH3_9

SH3_9: Variant SH3 domain (1520 - 1566)

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  • 1200
  • 1500
  • 1597 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 5

Rho guanine nucleotide exchange factor (GEF) 5

ARHGEF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
Intra
ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 POLR1C Homo sapiens O15160
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 POLR1C Homo sapiens O15160
Y2H Array
32296183
Intra
ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Y2H Array
32296183
Intra
ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Y2H Array
32296183
Intra
ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
ARHGEF5 Q12774 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Y2H Array
32296183
Intra
ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra
ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
25416956
Intra
ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
BFG-2H
27107012
Intra
ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra
ARHGEF5 Q12774 GRB2 Homo sapiens P62993
Anti Tag CoIP
32203420
Intra
ARHGEF5 Q12774 GRB2 Homo sapiens P62993
Anti Bait CoIP
24189400
Intra
ARHGEF5 Q12774 RHOA Homo sapiens P61586
Enzymatic Study
12006984
Intra
ARHGEF5 Q12774 SFN Homo sapiens P31947
TAP
15778465
Intra
ARHGEF5 Q12774 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Y2H Array
32296183
Intra
ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Array
25416956
Intra
ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Array
32296183
Intra
ARHGEF5 Q12774 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rippling Muscle Disease 2

Rippling Muscle Disease

Rmd

Lgmd1c

RMD2

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly

Lgmd1c, Formerly

Limb-Girdle Muscular Dystrophy Type 1c

Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency

Muscular Dystrophy, Limb-Girdle, Type Ic

Rippling Muscle Syndrome

Limb-Girdle Muscular Dystrophy 1c

Dystrophy, Muscular, Limb-Girdle, Type 1c

Disease, Muscle, Rippling, Type 2

Rippling Muscle Disease 1
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00962 ARHGEF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF5 VGNC VGNC:38090
Macaca mulatta ARHGEF5 VGNC VGNC:80793
Bos taurus ARHGEF5 VGNC VGNC:26119
Mus musculus ARHGEF5 MGD MGI:1858952
Rattus norvegicus ARHGEF5 RGD RGD:620718