1. Gene
  2. TNIP3 - TNFAIP3 interacting protein 3 Gene

TNIP3 - TNFAIP3 interacting protein 3 Gene

Homo sapiens

Also known as LIND; ABIN-3

Gene ID: 79931 | Gene type: protein coding

About TNIP3

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,131,408-121,227,483 (from NCBI)

This gene has 7 transcripts (splice variants), 116 orthologues and 2 paralogues. Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues.

Summary

Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and Toll-like Receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TNIP3 Products(3)

mRNA Protein Name
NM_001128843.2 NP_001122315.2 TNFAIP3-interacting protein 3 isoform 2
NM_001244764.2 NP_001231693.1 TNFAIP3-interacting protein 3 isoform 3
NM_024873.6 NP_079149.3 TNFAIP3-interacting protein 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18212736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in MyD88-independent toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
17088249 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17088249 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
17088249 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
17088249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNFAIP3-interacting protein 3

A20-binding inhibitor of NF-kappa-B activation 3

TNIP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TNIP3 Q96KP6 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra TNIP3 Q96KP6 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra TNIP3 Q96KP6 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra TNIP3 Q96KP6 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra TNIP3 Q96KP6 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra TNIP3 Q96KP6 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra TNIP3 Q96KP6 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra TNIP3 Q96KP6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025
Y2H Array
25416956
Intra TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra TNIP3 Q96KP6 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra TNIP3 Q96KP6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra TNIP3 Q96KP6 CCN3 Homo sapiens P48745
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 CCN3 Homo sapiens P48745
Y2H Array
32296183
Intra TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580
Validated Y2H
25416956
Intra TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580
Y2H Prey Pooling
25416956
Intra TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580
Y2H Array
25416956
Intra TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra TNIP3 Q96KP6 MAGEA2 Homo sapiens P43356
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 MAGEA2 Homo sapiens P43356
Y2H Array
32296183
Intra TNIP3 Q96KP6 FAM161A Homo sapiens Q3B820
Y2H Array
32296183
Intra TNIP3 Q96KP6 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038
Y2H Array
25416956
Intra TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
Intra TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra TNIP3 Q96KP6 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra TNIP3 Q96KP6 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra TNIP3 Q96KP6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNIP3 RGD RGD:1588732
Macaca mulatta TNIP3 VGNC VGNC:79193
Canis familiaris TNIP3 VGNC VGNC:47678
Mus musculus TNIP3 MGD MGI:3041165
Felis catus TNIP3 VGNC VGNC:66418
Bos taurus TNIP3 VGNC VGNC:36181