Tlr9 - toll-like receptor 9 Gene

Mus musculus

Gene ID: 81897 | Gene type: protein coding

About Tlr9

Chromosome 9: 106,099,797-106,104,082 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 81 orthologues, 24 paralogues and is associated with 24 phenotypes. Biased expression in spleen adult (RPKM 37.8), mammary gland adult (RPKM 11.5) and 5 other tissues.

Summary

Predicted to enable interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of defense response; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in intestine and small intestine mucosa. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2022]

Tlr9 Products(1)

mRNA	Protein	Name
NM_031178.2	NP_112455.2	toll-like receptor 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452530	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in MyD88-dependent toll-like receptor signaling pathway	IPI IPI: Inferred from physical interaction	18820679	MGI
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	25686612	MGI
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18820679	MGI
acts upstream of or within cellular response to chloroquine	IDA IDA: Inferred from direct assay	17475835	MGI
acts upstream of or within defense response to virus	IGI IGI: Inferred from genetic interaction	18250457	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	11130078	MGI
involved in maintenance of gastrointestinal epithelium	IMP IMP: Inferred from mutant phenotype	17128265	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	23109291	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	21402738	MGI
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-18 production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of intestinal epithelial cell development	IMP IMP: Inferred from mutant phenotype	17128265	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	18931679	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18931679	MGI
acts upstream of or within regulation of B cell activation	IGI IGI: Inferred from genetic interaction	23109291	MGI
acts upstream of or within regulation of dendritic cell cytokine production	IDA IDA: Inferred from direct assay	19047410	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	24740015	MGI
acts upstream of or within response to virus	IMP IMP: Inferred from mutant phenotype	14993594	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early phagosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in endolysosome	IDA IDA: Inferred from direct assay	25917084	MGI
located in endolysosome	IGI IGI: Inferred from genetic interaction	18820679	MGI
located in endolysosome	IMP IMP: Inferred from mutant phenotype	18931679	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18305481	MGI
located in endosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in lysosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in phagocytic vesicle	IGI IGI: Inferred from genetic interaction	18820679	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16415873	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr9 Protein Structure

PRK15370

LRR_RI

PLN00113

LRR_RI

LRR_12

LRR_RI

LRR_8

LRR_RI

TIR_2

0
200
400
600
800
1032 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 9

Tlr9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Tlr9	Q9EQU3	Atp2a2	Rattus norvegicus	P11507	Anti Tag CoIP	24610369
Cross	Tlr9	Q9EQU3	Atp2a2	Rattus norvegicus	P11507	TAP	24610369

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150218	Agatolimod sodium	Agonist	98.49%	Phase 3
HY-146244	Agatolimod	Agonist	/	Phase 3
HY-148511	Vidutolimod	Agonist	/	Phase 3
HY-150724	ODN 1018	Agonist	96.23%	Phase 2

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146245	ODN 1826	Agonist	/	Unkown
HY-146245C	ODN 1826 sodium	Agonist	99.51%	Unkown
HY-N0201	Atractylenolide I	Antagonist	99.94%	Unkown
HY-150741	ODN 2216	Agonist	/	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-150743	ODN 2395	Agonist	98.39%	Unkown
HY-150743C	ODN 2395 sodium	Agonist	/	Unkown
HY-150726	ODN 1668	Agonist	/	Unkown
HY-148045	TLR9-IN-1	Inhibitor	99.80%	Unkown
HY-150726C	ODN 1668 sodium	Agonist	≥99.0%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.96%	Unkown
HY-150217	CpG ODN 10101	Agonist	/	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-150736	ODN 20844	Inhibitor	/	Unkown
HY-150750	ODN M362	Agonist	/	Unkown
HY-12756	E6446	Antagonist	≥98.0%	Unkown
HY-150745	ODN 24987	Inhibitor	/	Unkown
HY-146245F	FAM-labeled ODN 1826 sodium	Agonist	98.03%	Unkown
HY-B1370R	Hydroxychloroquine (sulfate) (Standard)	Inhibitor	99.28%	Unkown
HY-150219A	ODN M326 sodium	Inhibitor	/	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-114592	M199	Inhibitor	/	Unkown
HY-150219	ODN M326	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr9	NCBI	NCBI:54106

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