UBL4A - ubiquitin like 4A Gene

Homo sapiens

Also known as GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E

Gene ID: 8266 | Gene type: protein coding

About UBL4A

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,483,717-154,486,615 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 10 paralogues. Ubiquitous expression in heart (RPKM 16.9), brain (RPKM 12.9) and 25 other tissues.

Summary

Enables chaperone binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]

UBL4A Products(1)

mRNA	Protein	Name
NM_014235.5	NP_055050.1	ubiquitin-like protein 4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	25535373	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in post-translational protein targeting to endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25535373	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	21636303	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	25535373	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	20676083	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20676083	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BAT3 complex	IDA IDA: Inferred from direct assay	20676083	GOA
part of BAT3 complex	IPI IPI: Inferred from physical interaction	25535373	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21636303	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20676083	GOA
located in membrane	IDA IDA: Inferred from direct assay	23246001	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21636303	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBL4A Protein Structure

ubiquitin

0
100
157 a.a.

Protein Preferred Names

Protein Names

ubiquitin-like protein 4A

ubiquitin-like 4

UBL4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBL4A	P11441	PER2	Homo sapiens	O15055	Y2H Prey Pooling	32296183
Intra	UBL4A	P11441	PER2	Homo sapiens	O15055	Y2H Array	32296183
Intra	UBL4A	P11441	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	UBL4A	P11441	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	UBL4A	P11441	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	UBL4A	P11441	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	UBL4A	P11441	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	UBL4A	P11441	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	UBL4A	P11441	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	UBL4A	P11441	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	UBL4A	P11441	SGTA	Homo sapiens	O43765	Anti Tag CoIP	19615732
Intra	UBL4A	P11441	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	UBL4A	P11441	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	UBL4A	P11441	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	UBL4A	P11441	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	UBL4A	P11441	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	UBL4A	P11441	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	UBL4A	P11441	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	25416956
Intra	UBL4A	P11441	S100P	Homo sapiens	P25815	Y2H Array	32296183
Intra	UBL4A	P11441	S100P	Homo sapiens	P25815	Validated Y2H	32296183
Intra	UBL4A	P11441	S100P	Homo sapiens	P25815	Y2H Prey Pooling	32296183
Intra	UBL4A	P11441	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	UBL4A	P11441	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	UBL4A	P11441	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	UBL4A	P11441	ERP27	Homo sapiens	Q96DN0	Validated Y2H	32296183
Intra	UBL4A	P11441	ERP27	Homo sapiens	Q96DN0	Y2H Array	32296183
Intra	UBL4A	P11441	ERP27	Homo sapiens	Q96DN0	Y2H Prey Pooling	32296183
Cross	UBL4A	P11441	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15375	UBL4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBL4A	VGNC	VGNC:78702
Felis catus	UBL4A	VGNC	VGNC:66774
Mus musculus	UBL4A	MGD	MGI:95049
Rattus norvegicus	UBL4A	RGD	RGD:1563983
Canis familiaris	UBL4A	VGNC	VGNC:48077

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