2. Gene
  3. Kl - Klotho Gene

Kl - Klotho Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83504 | Gene type: protein coding

About Kl

Summary

Predicted to enable Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]

Kl Products(1)

mRNA Protein Name
NM_031336.2 NP_112626.1 klotho precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
20086041 RGD
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
20086041 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22891896 RGD
involved in response to angiotensin IEP
IEP: Inferred from expression pattern
11967236 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
17992255 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
20631679 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

klotho

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13204A Biperiden Inhibitor 99.74% Unkown
HY-13204 Biperiden hydrochloride Inhibitor 99.90% Unkown
HY-13204B Biperiden lactate Inhibitor / Unkown
HY-13204R Biperiden (hydrochloride) (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-128895 KL1333 Modulator 99.89% Phase 2
HY-108468 KL001 99.68% Phase 1
HY-19842 GS-9667 Agonist 98.08% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145597 KL-11743 98.77% Unkown
HY-D0286 Fluorol Yellow 088 ≥98.0% Unkown
HY-123972 SEC inhibitor KL-2 Inhibitor 99.80% Unkown
HY-122720 SEC inhibitor KL-1 Activator 99.58% Unkown
HY-119506 KL044 99.05% Unkown
HY-134194 KL201 98.15% Unkown
HY-164496 KL-50 Inhibitor 99.82% Unkown
HY-121849 KL-1156 Inhibitor / Unkown
HY-13204S Biperiden-d5 hydrochloride Inhibitor / Unkown
HY-143969S KL140061A-d4 / Unkown
HY-155972 CRM1-IN-1 Inhibitor / Unkown
HY-155972A CRM1-IN-2 / Unkown
HY-169086 KL-465 / Unkown
HY-RS07324 KL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-13204AS Biperiden-d5 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990184 Anti-Mouse MHC Class II (βchain) Antibody (KL277) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kl NCBI NCBI:9365
Macaca fascicularis Kl NCBI NCBI:102115572
Mus musculus Kl NCBI NCBI:16591
Macaca mulatta Kl NCBI NCBI:714042