ATG13 - autophagy related 13 Gene

Homo sapiens

Also known as KIAA0652; PARATARG8

Gene ID: 9776 | Gene type: protein coding

About ATG13

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,617,553-46,674,518 (from NCBI)

This gene has 31 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues.

Summary

The protein encoded by this gene is an Autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and Mitophagy. [provided by RefSeq, Oct 2016]

ATG13 Products(51)

mRNA	Protein	Name
NM_001142673.3	NP_001136145.1	autophagy-related protein 13 isoform c
NM_001205119.2	NP_001192048.1	autophagy-related protein 13 isoform a
NM_001205120.2	NP_001192049.1	autophagy-related protein 13 isoform c
NM_001205121.2	NP_001192050.1	autophagy-related protein 13 isoform f
NM_001205122.2	NP_001192051.1	autophagy-related protein 13 isoform h
NM_001346311.2	NP_001333240.1	autophagy-related protein 13 isoform a
NM_001346312.2	NP_001333241.1	autophagy-related protein 13 isoform a
NM_001346313.2	NP_001333242.1	autophagy-related protein 13 isoform a
NM_001346314.2	NP_001333243.1	autophagy-related protein 13 isoform a
NM_001346315.2	NP_001333244.1	autophagy-related protein 13 isoform a
NM_001346316.2	NP_001333245.1	autophagy-related protein 13 isoform a
NM_001346317.2	NP_001333246.1	autophagy-related protein 13 isoform b
NM_001346318.2	NP_001333247.1	autophagy-related protein 13 isoform b
NM_001346319.2	NP_001333248.1	autophagy-related protein 13 isoform c
NM_001346320.2	NP_001333249.1	autophagy-related protein 13 isoform c
NM_001346321.2	NP_001333250.1	autophagy-related protein 13 isoform c
NM_001346322.2	NP_001333251.1	autophagy-related protein 13 isoform c
NM_001346323.2	NP_001333252.1	autophagy-related protein 13 isoform c
NM_001346324.2	NP_001333253.1	autophagy-related protein 13 isoform c
NM_001346325.2	NP_001333254.1	autophagy-related protein 13 isoform c
NM_001346326.2	NP_001333255.1	autophagy-related protein 13 isoform c
NM_001346327.2	NP_001333256.1	autophagy-related protein 13 isoform c
NM_001346328.2	NP_001333257.1	autophagy-related protein 13 isoform c
NM_001346329.2	NP_001333258.1	autophagy-related protein 13 isoform c
NM_001346330.2	NP_001333259.1	autophagy-related protein 13 isoform c
NM_001346331.2	NP_001333260.1	autophagy-related protein 13 isoform c
NM_001346332.2	NP_001333261.1	autophagy-related protein 13 isoform c
NM_001346333.2	NP_001333262.1	autophagy-related protein 13 isoform d
NM_001346334.2	NP_001333263.1	autophagy-related protein 13 isoform d
NM_001346335.2	NP_001333264.1	autophagy-related protein 13 isoform d
NM_001346336.2	NP_001333265.1	autophagy-related protein 13 isoform d
NM_001346337.2	NP_001333266.1	autophagy-related protein 13 isoform d
NM_001346338.2	NP_001333267.1	autophagy-related protein 13 isoform e
NM_001346340.2	NP_001333269.1	autophagy-related protein 13 isoform e
NM_001346342.2	NP_001333271.1	autophagy-related protein 13 isoform f
NM_001346344.2	NP_001333273.1	autophagy-related protein 13 isoform f
NM_001346346.2	NP_001333275.1	autophagy-related protein 13 isoform f
NM_001346348.2	NP_001333277.1	autophagy-related protein 13 isoform f
NM_001346349.2	NP_001333278.1	autophagy-related protein 13 isoform f
NM_001346350.2	NP_001333279.1	autophagy-related protein 13 isoform f
NM_001346351.2	NP_001333280.1	autophagy-related protein 13 isoform f
NM_001346352.2	NP_001333281.1	autophagy-related protein 13 isoform f
NM_001346353.2	NP_001333282.1	autophagy-related protein 13 isoform f
NM_001346354.2	NP_001333283.1	autophagy-related protein 13 isoform f
NM_001346355.2	NP_001333284.1	autophagy-related protein 13 isoform g
NM_001346356.2	NP_001333285.1	autophagy-related protein 13 isoform g
NM_001346357.2	NP_001333286.1	autophagy-related protein 13 isoform i
NM_001346358.2	NP_001333287.1	autophagy-related protein 13 isoform i
NM_001346359.2	NP_001333288.1	autophagy-related protein 13 isoform i
NM_001346360.2	NP_001333289.1	autophagy-related protein 13 isoform j
NM_014741.5	NP_055556.2	autophagy-related protein 13 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19211835	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	29487085	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18936157	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	19225151	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	GOA
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19211835	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19211835	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	29487085	GOA
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19211835	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21855797	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	19597335	GOA
is active in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	19597335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG13 Protein Structure

ATG13

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

autophagy-related protein 13

ATG13 autophagy related 13 homolog

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01141	ATG13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATG13	VGNC	VGNC:38217
Macaca mulatta	ATG13	VGNC	VGNC:70148
Bos taurus	ATG13	VGNC	VGNC:26251
Rattus norvegicus	ATG13	RGD	RGD:1310685
Felis catus	ATG13	VGNC	VGNC:59996
Mus musculus	ATG13	MGD	MGI:1196429

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