Hdac5 - histone deacetylase 5 Gene

Rattus norvegicus

Gene ID: 84580 | Gene type: protein coding

About Hdac5

Primary_assembly 10: 87,152,978-87,188,235 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 194 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 189.9), Brain (RPKM 149.1) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to activity; and response to cocaine. Located in cytoplasm and nucleus. Part of protein-containing complex. Biomarker of acute kidney failure; mental depression; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products(1)

mRNA	Protein	Name
NM_053450.1	NP_445902.1	histone deacetylase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19638401	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	22933299	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	12850547	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	21198979	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	21954104	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16767219	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12896970	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12896970	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22360269	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

Arginase_HDAC

0
200
400
600
800
1000
1120 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 5

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-112719	BRD 4354	Inhibitor	99.66%	Unkown
HY-143248	KR-39038	Inhibitor	99.48%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac5	NCBI	NCBI:10014

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