STK24 - serine/threonine kinase 24 Gene

Homo sapiens

Also known as MST3; STK3; MST3B; STE20; HEL-S-95

Gene ID: 8428 | Gene type: protein coding

About STK24

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:98,445,185-98,577,107 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

STK24 Products(3)

mRNA	Protein	Name
NM_001032296.4	NP_001027467.2	serine/threonine-protein kinase 24 isoform b precursor
NM_001286649.2	NP_001273578.1	serine/threonine-protein kinase 24 isoform c precursor
NM_003576.5	NP_003567.2	serine/threonine-protein kinase 24 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16314523	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22291017	GOA
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	12107159	GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19604147	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17046825	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17046825	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19604147	GOA
involved in regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	19855390	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12107159	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12107159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK24 Protein Structure

Pkinase

0
100
200
300
400
443 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 24

STE20-like kinase 3

STK24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Bait CoIP	17353931
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	TAP	23455922
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Pull Down	32707033
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Pull Down	32707033
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	Pull Down	32707033
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	TAP	23455922
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Bait CoIP	17353931
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H Array	31515488
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H	17657516
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	TAP	23455922
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Pull Down	32707033
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H	21516116
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H Pooling	16189514
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	18782753

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Inflammatory Bowel Disease 14

IBD14	Inflammatory Bowel Disease 14, Susceptibility To
Bowel Disease, Inflammatory, Type 14

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Arthrogryposis, Distal, Type 3

Gordon Syndrome	DA3
Distal Arthrogryposis Type 3	Arthrogryposis Multiplex Congenita, Distal, Type Iia
Camptodactyly, Cleft Palate, And Clubfoot	Camptodactyly-Cleft Palate-Clubfoot Syndrome
Distal Arthrogryposis Multiplex Congenita Type Iia	Arthrogryposis Distal Type 3
Distal Arthrogryposis Type Iia	Arthrogryposis, Distal, 3
Pseudohypoaldosteronism, Type Ii

Gitelman Syndrome

Familial Hypokalemia-Hypomagnesemia	Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria
Potassium And Magnesium Depletion	GTLMNS
Gitelman'S Syndrome	Gs
Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria	Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria
Bartter Syndrome Gitelman Variant	Bartter Syndrome Hypocalciuric Variant
Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria

Pseudohypoaldosteronism

Agenesis Of The Corpus Callosum With Peripheral Neuropathy

Andermann Syndrome	Charlevoix Disease
ACCPN	Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum
Corpus Callosum, Agenesis Of, With Neuronopathy	Corpus Callosum Agenesis-Neuronopathy Syndrome
Agenesis Of Corpus Callosum With Neuronopathy	Agenesis Of Corpus Callosum With Peripheral Neuropathy
Agenesis Of Corpus Callosum With Polyneuropathy	Corpus Callosum Agenesis Neuronopathy
Hmsn/Acc	Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum
Agenesis Of The Corpus Callosum, With Peripheral Neuropathy	Andermann'S Syndrome
Agenesis, Corpus Callosum, With Peripheral Neuropathy

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13927	STK24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STK24	MGD	MGI:2385007
Macaca mulatta	STK24	VGNC	VGNC:81583
Felis catus	STK24	VGNC	VGNC:97647
Bos taurus	STK24	VGNC	VGNC:35390
Rattus norvegicus	STK24	RGD	RGD:1561742
Canis familiaris	STK24	VGNC	VGNC:49657
Others	STK24	NCBI

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