1. Gene
  2. CAV2 - caveolin 2 Gene

CAV2 - caveolin 2 Gene

Homo sapiens

Also known as CAV

Gene ID: 858 | Gene type: protein coding

About CAV2

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,499,738-116,508,541 (from NCBI)

This gene has 15 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in fat (RPKM 133.6), lung (RPKM 106.3) and 17 other tissues.

Summary

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and Apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

CAV2 Products(4)

mRNA Protein Name
NM_001206747.2 NP_001193676.1 caveolin-2 isoform b
NM_001206748.2 NP_001193677.1 caveolin-2 isoform d
NM_001233.5 NP_001224.1 caveolin-2 isoform a
NM_198212.3 NP_937855.1 caveolin-2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
15569306 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10212252 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8552590 GOA
Biological Process GO Annotation Evidence Reference Source
involved in caveola assembly IDA
IDA: Inferred from direct assay
12743374 GOA
involved in caveola assembly IMP
IMP: Inferred from mutant phenotype
12633858 GOA
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
20455999 GOA
involved in positive regulation by host of viral process IMP
IMP: Inferred from mutant phenotype
25556234 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
8552590 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
20455999 GOA
involved in positive regulation of dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15569306 GOA
involved in receptor-mediated endocytosis of virus by host cell IGI
IGI: Inferred from genetic interaction
21047970 GOA
involved in regulation of mitotic nuclear division IEP
IEP: Inferred from expression pattern
18081315 GOA
involved in vesicle docking IDA
IDA: Inferred from direct assay
12743374 GOA
involved in vesicle fusion IDA
IDA: Inferred from direct assay
12743374 GOA
involved in vesicle organization IDA
IDA: Inferred from direct assay
12743374 GOA
involved in viral release from host cell IMP
IMP: Inferred from mutant phenotype
25556234 GOA
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
8552590 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
22792322 GOA
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
12091389 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
11294831 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18081315 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8552590 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
15569306 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
24013648 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAV2 Protein Structure

Caveolin

Caveolin: Caveolin (16 - 161)

  • 0
  • 100
  • 162 a.a.
Protein Preferred Names Protein Names

caveolin-2

caveolae protein, 20-kD

Related Diseases

Diseases Alias
Lung Pleomorphic Carcinoma
Episodic Ataxia, Type 2

Episodic Ataxia Type 2

EA2

Apca

Capa

Cerebellopathy, Hereditary Paroxysmal

Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia

Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive

Episodic Ataxia With Nystagmus

Ataxia, Episodic, With Nystagmus

Episodic Ataxia, Nystagmus-Associated

Ataxia, Familial Paroxysmal

Acetazolamide-Responsive Episodic Ataxia Syndrome

Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia

Ataxia, Familial, Paroxysmal

Nystagmus-Associated Episodic Ataxia

Familial Paroxysmal Ataxia

Episodic Ataxia 2

Ea-2

Episodic Ataxia Nystagmus-Associated

Hereditary Paroxysmal Cerebellopathy

Ataxia, Episodic, Type 2

Brill-Zinsser Disease

Recrudescent Typhus

Brill Disease

Brill Zinsser Disease

Brill'S Disease

Latent Typhus

Sporadic Typhus

Typhus, Epidemic Louse-Borne

Recrudescent Typhus Due To Rickettsia Prowazekii

Recrudescent Typhus Fever

Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

Recrudescent Brill Disease

Recrudescent Typhus Fever Due To Rickettsia Prowazekii

Rippling Muscle Disease 2

Rippling Muscle Disease

Rmd

Lgmd1c

RMD2

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly

Lgmd1c, Formerly

Limb-Girdle Muscular Dystrophy Type 1c

Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency

Muscular Dystrophy, Limb-Girdle, Type Ic

Rippling Muscle Syndrome

Limb-Girdle Muscular Dystrophy 1c

Dystrophy, Muscular, Limb-Girdle, Type 1c

Disease, Muscle, Rippling, Type 2

Rippling Muscle Disease 1

Queensland Tick Typhus

Australian Tick Typhus

North Queensland Tick Typhus

Rickettsia Australis Spotted Fever

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary

Glaucoma, Normal Tension

Low Tension Glaucoma

Glaucoma, Normal Tension, Susceptibility To

Normal Tension Glaucoma

Ntg

Glaucoma, Normal Pressure

NPG

Glaucoma, Normal Pressure, Susceptibility To

Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Lipodystrophy, Congenital Generalized, Type 3

Congenital Generalized Lipodystrophy Type 3

CGL3

Bscl3

Berardinelli-Seip Congenital Lipodystrophy Type 3

Berardinelli-Seip Congenital Lipodystrophy, Type 3

Lipodystrophy, Berardinelli-Seip Congenital, Type 3

Type 3 Berardinelli-Seip Congenital Lipodystrophy

Congenital Generalized Lipodystrophy 3

Spinocerebellar Ataxia 6

Spinocerebellar Ataxia Type 6

SCA6

Type 6 Spinocerebellar Ataxia

Spinocerebellar Ataxia-6

Ataxia, Spinocerebellar, Type 6

Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma

Isolated Elevated Serum Creatine Phosphokinase Levels

Elevated Serum Cpk

Idiopathic Hyperckemia

Isolated Hyperckemia

Elevated Serum Creatine Phosphokinase

H-Ck

Idiopathic Persistent Elevation Of Serum Creatine Kinase

Episodic Ataxia

Isaacs Syndrome

Neuromyotonia

Isaacs' Syndrome

Acquired Neuromyotonia

Continuous Muscle Fiber Activity Syndrome

Quantal Squander Syndrome

Isaacs-Mertens Syndrome

Ea Syndrome

Episodic Ataxia Syndrome

Isaac Syndrome

Isaac'S-Merten'S Syndrome

Isaac-Mertens Syndrome

Peripheral Nerve Hyperexcitability

Ea

Peripheral Nerve Hyperexcitability Syndrome

Ataxia, Episodic

Isaacs Neuromyotonia

Continuous Muscle Fibre Activity

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAV2 RGD RGD:620348
Canis familiaris CAV2 VGNC VGNC:38752
Macaca mulatta CAV2 VGNC VGNC:80806
Bos taurus CAV2 VGNC VGNC:26800
Mus musculus CAV2 MGD MGI:107571
Felis catus CAV2 VGNC VGNC:60399