EIF3G - eukaryotic translation initiation factor 3 subunit G Gene

Homo sapiens

Also known as EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta

Gene ID: 8666 | Gene type: protein coding

About EIF3G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,115,014-10,119,899 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues.

Summary

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal Caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

EIF3G Products(1)

mRNA	Protein	Name
NM_003755.5	NP_003746.2	eukaryotic translation initiation factor 3 subunit G

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	25849773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14688252	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA
involved in viral translational termination-reinitiation	IDA IDA: Inferred from direct assay	21347434	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3G Protein Structure

eIF3g

RRM_1

0
100
200
300
320 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit G

eukaryotic translation initiation factor 3 RNA-binding subunit

EIF3G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3G	O75821	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	EIF3G	O75821	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Pull Down	20406461
Intra	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Anti Tag CoIP	20406461
Intra	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Y2H	20406461
Intra	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Anti Bait CoIP	20406461
Intra	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	BiFC	20406461
Intra	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	33961781
Intra	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	28514442
Intra	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	35271311
Intra	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Y2H Array	17094969
Intra	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	SLCA	18599441
Intra	EIF3G	O75821	AIFM1	Homo sapiens	O95831	Pull Down	17094969
Intra	EIF3G	O75821	AIFM1	Homo sapiens	O95831	Y2H Array	17094969
Intra	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	24396066
Intra	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	35271311
Intra	EIF3G	O75821	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EIF3G	O75821	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EIF3G	O75821	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	EIF3G	O75821	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	EIF3G	O75821	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Array	32296183
Intra	EIF3G	O75821	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF3G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700506	EIF3G Protein, Human (His-SUMO)	O75821 (P2-N320)	≥95%

Related Diseases

Diseases

Alias

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04263	EIF3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3G	RGD	RGD:1307191
Canis familiaris	EIF3G	VGNC	VGNC:40273
Bos taurus	EIF3G	VGNC	VGNC:28397
Macaca mulatta	EIF3G	VGNC	VGNC:72190
Felis catus	EIF3G	VGNC	VGNC:61783
Mus musculus	EIF3G	MGD	MGI:1858258
Others	EIF3G	NCBI

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