PELO - pelota mRNA surveillance and ribosome rescue factor Gene

Homo sapiens

Also known as CGI-17; PRO1770

Gene ID: 53918 | Gene type: protein coding

About PELO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,804,044 (from NCBI)

This gene has 2 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in adrenal (RPKM 14.2), spleen (RPKM 12.3) and 25 other tissues.

Summary

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

PELO Products(1)

mRNA	Protein	Name
NM_015946.5	NP_057030.3	protein pelota homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20406461	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	27543824	GOA
enables stalled ribosome sensor activity	IDA IDA: Inferred from direct assay	27863242	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nuclear-transcribed mRNA catabolic process, no-go decay	IDA IDA: Inferred from direct assay	23667253	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	21448132	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	21448132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Dom34-Hbs1 complex	IDA IDA: Inferred from direct assay	27863242	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	27863242	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELO Protein Structure

eRF1_1

eRF1_2

eRF1_3

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

protein pelota homolog

pelota homolog

Related Diseases

Diseases

Alias

Progressive Myoclonus Epilepsy 10

Early-Onset Lafora Body Disease

Epm10

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10323	PELO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PELO	MGD	MGI:2145154
Rattus norvegicus	PELO	RGD	RGD:1359591
Bos taurus	PELO	VGNC	VGNC:32743
Felis catus	PELO	VGNC	VGNC:102287
Macaca mulatta	PELO	VGNC	VGNC:84478

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