MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene

Homo sapiens

Also known as HS; NIK; HSNIK; FTDCR1B

Gene ID: 9020 | Gene type: protein coding

About MAP3K14

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,263,119-45,317,020 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 241 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several Other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

MAP3K14 Products(1)

mRNA	Protein	Name
NM_003954.5	NP_003945.2	mitogen-activated protein kinase kinase kinase 14

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9020361	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	15001576	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	9520446	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	10094049	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 14

NF-kappa-beta-inducing kinase

MAP3K14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K14	Q99558	RPS11	Homo sapiens	P62280	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	KPNB1	Homo sapiens	Q14974	Pull Down	30833792
Intra	MAP3K14	Q99558	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	MAP3K14	Q99558	CDC37	Homo sapiens	Q16543	Pull Down	30833792
Intra	MAP3K14	Q99558	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	MAP3K14	Q99558	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	HSP90AA1	Homo sapiens	P07900	Pull Down	30833792
Intra	MAP3K14	Q99558	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	MAP3K14	Q99558	RPL4	Homo sapiens	P36578	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	MAP3K14	Q99558	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	MAP3K14	Q99558	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	MAP3K14	Q99558	RPS13	Homo sapiens	P62277	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MAP3K14	Q99558	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	MAP3K14	Q99558	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	TRAF2	Homo sapiens	Q12933	Y2H	9020361
Intra	MAP3K14	Q99558	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	MAP3K14	Q99558	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Y2H Prey Pooling	32296183
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Y2H Array	32296183
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	33961781
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	28514442
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Pull Down	32707033
Intra	MAP3K14	Q99558	TRAF3	Homo sapiens	Q13114	Pull Down	30833792
Intra	MAP3K14	Q99558	RPL6	Homo sapiens	Q02878	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	RPL8	Homo sapiens	P62917	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Pull Down	30833792
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Pull Down	32707033
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Protein Kinase Assay	9520446
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Anti Bait CoIP	16498412
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Anti Tag CoIP	28514442
Intra	MAP3K14	Q99558	CHUK	Homo sapiens	O15111	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33961781
Intra	MAP3K14	Q99558	IKBKB	Homo sapiens	O14920	Pull Down	30833792
Intra	MAP3K14	Q99558	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	28514442
Intra	MAP3K14	Q99558	IKBKB	Homo sapiens	O14920	Pull Down	32707033
Intra	MAP3K14	Q99558	IKBKB	Homo sapiens	O14920	Protein Kinase Assay	9520446
Intra	MAP3K14	Q99558	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	31980649
Intra	MAP3K14	Q99558	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	33961781
Intra	MAP3K14	Q99558	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	32707033

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nik Deficiency

Primary Immunodeficiency With Multifaceted Aberrant Lymphoid Immunity

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency	IMD50
Immunodeficiency 50, X-Linked Recessive	Cid Due To Moesin Deficiency
Msn-Related Combined Immunodeficiency	X-Linked Moesin-Associated Immunodeficiency
Immunodeficiency 50 X Linked Recessive

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08051	MAP3K14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP3K14	RGD	RGD:1310487
Bos taurus	MAP3K14	VGNC	VGNC:31192
Felis catus	MAP3K14	VGNC	VGNC:99219
Mus musculus	MAP3K14	MGD	MGI:1858204
Macaca mulatta	MAP3K14	VGNC	VGNC:81459
Canis familiaris	MAP3K14	VGNC	VGNC:42970

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