WTAP - WT1 associated protein Gene

Homo sapiens

Also known as Mum2

Gene ID: 9589 | Gene type: protein coding

About WTAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,726,693-159,756,319 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues.

Summary

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

WTAP Products(6)

mRNA	Protein	Name
NM_001270531.2	NP_001257460.1	pre-mRNA-splicing regulator WTAP isoform 1
NM_001270532.2	NP_001257461.1	pre-mRNA-splicing regulator WTAP isoform 3
NM_001270533.2	NP_001257462.1	pre-mRNA-splicing regulator WTAP isoform 3
NM_004906.5	NP_004897.2	pre-mRNA-splicing regulator WTAP isoform 1
NM_152857.3	NP_690596.1	pre-mRNA-splicing regulator WTAP isoform 2
NM_152858.3	NP_690597.1	pre-mRNA-splicing regulator WTAP isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	24316715	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	24407421	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	24316715	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: Inferred from physical interaction	29507755	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	10942595	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	24100041	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24100041	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-mRNA-splicing regulator WTAP

PNAS-132

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Wilms Tumor 5

Wilms Tumor	WT5
Wilms Tumor Susceptibility-5	Wilms Tumor And Radial Bilateral Aplasia
Nephroblastoma	Wilms' Tumor
Wilms Tumor, Susceptibility To	Wtsl
Bilateral Radial Aplasia With Wilms Tumor	Embryonal Adenosarcoma
Embryonal Nephroma	Kidney Wilms Tumor
Kidney, Adenomyosarcoma, Embryonal	Kidney, Carcinosarcoma, Embryonal
Kidney, Embryoma	Kidney, Embryonal Mixed Tumor
Nephroma	Renal Adenosarcoma
Renal Cancer, Wilms	Renal Wilms Tumor
Tumor, Wilms	Hereditary Susceptibility To Wilms Tumor 5

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15854	WTAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WTAP	RGD	RGD:1563824
Mus musculus	WTAP	MGD	MGI:1926395
Macaca mulatta	WTAP	VGNC	VGNC:83971
Felis catus	WTAP	VGNC	VGNC:84872
Canis familiaris	WTAP	VGNC	VGNC:54003
Bos taurus	WTAP	VGNC	VGNC:103059

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