2. Gene
  3. CDC25B - cell division cycle 25B Gene

CDC25B - cell division cycle 25B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 994 | Gene type: protein coding

About CDC25B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,786,951-3,806,115 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues.

Summary

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

CDC25B Products(10)

mRNA Protein Name
NM_001287516.2 NP_001274445.1 M-phase inducer phosphatase 2 isoform 4
NM_001287517.2 NP_001274446.1 M-phase inducer phosphatase 2 isoform 5
NM_001287518.2 NP_001274447.1 M-phase inducer phosphatase 2 isoform 6
NM_001287519.2 NP_001274448.1 M-phase inducer phosphatase 2 isoform 7
NM_001287520.2 NP_001274449.1 M-phase inducer phosphatase 2 isoform 7
NM_001287522.2 NP_001274451.1 M-phase inducer phosphatase 2 isoform 8
NM_001287524.2 NP_001274453.1 M-phase inducer phosphatase 2 isoform 9
NM_004358.5 NP_004349.1 M-phase inducer phosphatase 2 isoform 2
NM_021872.4 NP_068658.1 M-phase inducer phosphatase 2 isoform 3
NM_021873.4 NP_068659.1 M-phase inducer phosphatase 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
20360007 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7644510 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12400006 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
20360007 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
17332740 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
17332740 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17332740 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
15908796 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
15908796 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC25B Protein Structure

M-inducer_phosp

M-inducer_phosp: M-phase inducer phosphatase (113 - 384)

Rhodanese

Rhodanese: Rhodanese-like domain (433 - 529)

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  • 580 a.a.
Protein Preferred Names Protein Names

M-phase inducer phosphatase 2

CDC25 homolog B

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100034 NSC 663284 Inhibitor 99.79% Unkown
HY-108543 NSC 95397 ≥99.0% Unkown
HY-135457 JMS-053 ≥98.0% Unkown
HY-112776A BN82002 hydrochloride Inhibitor 99.36% Unkown
HY-151986 FOXM1-IN-1 Inhibitor 99.54% Unkown
HY-128769 M2N12 Inhibitor 98.19% Unkown
HY-126246 CDC25B-IN-1 Inhibitor 98.09% Unkown
HY-121065 BN-82685 Inhibitor 99.05% Unkown
HY-132578 M5N36 Inhibitor 98.05% Unkown
HY-112776 BN82002 Inhibitor / Unkown
HY-137175A CDC25B-IN-2 Inhibitor 97.01% Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-135564B (Rac)-RK-682 Inhibitor / Unkown
HY-RS02292 CDC25B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W024644 Hydroxyethylthio Vitamine K3 ≥97.0% Unkown
HY-N12177 Cryptosporioptide A Inhibitor / Unkown
HY-W102931 6,7-Dichloroquinoline-5,8-dione Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CDC25B MGD MGI:99701
Macaca mulatta CDC25B VGNC VGNC:70795
Felis catus CDC25B VGNC VGNC:60650
Bos taurus CDC25B VGNC VGNC:27063
Rattus norvegicus CDC25B RGD RGD:621500
Canis familiaris CDC25B VGNC VGNC:38990