2. Others Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Isotope-Labeled Compounds ADC Cytotoxin Topoisomerase
  4. Glycyl-Exatecan-d5 hydrochloride

Glycyl-Exatecan-d5 hydrochloride  (Synonyms: Glycyl-DX-8951-d5 hydrochloride; Exatecan analog 2-d5 hydrochloride)

Cat. No.: HY-128995AS Purity: 95.08%
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Glycyl-Exatecan-d5 (hydrochloride) is deuterium labeled Glycyl-Exatecan.

For research use only. We do not sell to patients.

Glycyl-Exatecan-d<sub>5</sub> hydrochloride Chemical Structure

Glycyl-Exatecan-d5 hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 1500 In-stock
5 mg USD 3750 In-stock
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Glycyl-Exatecan-d5 hydrochloride Related Antibodies

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Description

Glycyl-Exatecan-d5 (hydrochloride) is deuterium labeled Glycyl-Exatecan.

Molecular Weight

533.99

Formula

C26H21D5ClFN4O5
Unlabeled CAS

1883333-57-0
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC(C=C1N=C2C3=CC([C@](O)4C(C([2H])([2H])[2H])([2H])[2H])=C5COC4=O)=C(C)C6=C1C([C@@H](NC(CN)=O)CC6)=C2CN3C5=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (206.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8727 mL 9.3635 mL 18.7269 mL
5 mM 0.3745 mL 1.8727 mL 3.7454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.75 mg/mL (5.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.75 mg/mL (5.15 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.75 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8727 mL 9.3635 mL 18.7269 mL 46.8174 mL
5 mM 0.3745 mL 1.8727 mL 3.7454 mL 9.3635 mL
10 mM 0.1873 mL 0.9363 mL 1.8727 mL 4.6817 mL
15 mM 0.1248 mL 0.6242 mL 1.2485 mL 3.1212 mL
20 mM 0.0936 mL 0.4682 mL 0.9363 mL 2.3409 mL
25 mM 0.0749 mL 0.3745 mL 0.7491 mL 1.8727 mL
30 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5606 mL
40 mM 0.0468 mL 0.2341 mL 0.4682 mL 1.1704 mL
50 mM 0.0375 mL 0.1873 mL 0.3745 mL 0.9363 mL
60 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
80 mM 0.0234 mL 0.1170 mL 0.2341 mL 0.5852 mL
100 mM 0.0187 mL 0.0936 mL 0.1873 mL 0.4682 mL
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Glycyl-Exatecan-d5 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycyl-Exatecan-d5Glycyl-DX-8951-d5Exatecan analog 2-d5Isotope-Labeled CompoundsADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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