1. GPCR/G Protein Neuronal Signaling Anti-infection
  2. Adrenergic Receptor Parasite
  3. Guanabenz

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure.

For research use only. We do not sell to patients.

Guanabenz Chemical Structure

Guanabenz Chemical Structure

CAS No. : 5051-62-7

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Based on 2 publication(s) in Google Scholar

Other Forms of Guanabenz:

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  • Biological Activity

  • Purity & Documentation

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Description

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

IC50 & Target

Toxoplasma

 

In Vitro

Guanabenz (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability[1].
Guanabenz (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP[1].
Guanabenz (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect cell survival.

RT-PCR[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect levels of UPR targets.

Western Blot Analysis[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Increased the levels of low panel concentration-dependent UPR targets proteins.
In Vivo

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden[2].
Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice[2].
Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg
Administration: 5 mg/kg/day; i.p. ; for 3 weeks
Result: Reduced the latent brain cysts in both male and female BALB/cJ mice.
Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg; 10 mg/kg
Administration: 5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks
Result: Reversed parasite-induced hyperactivity to near-baseline levels.
Animal Model: Cats[3]
Dosage: 100 and 320 μg/kg and 1 mg/kg
Administration: 100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
Result: Declined markedly blood pressure and nerve activity.
Clinical Trial
Molecular Weight

231.08

Formula

C8H8Cl2N4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (108.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3275 mL 21.6375 mL 43.2751 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3275 mL 21.6375 mL 43.2751 mL 108.1876 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL 21.6375 mL
10 mM 0.4328 mL 2.1638 mL 4.3275 mL 10.8188 mL
15 mM 0.2885 mL 1.4425 mL 2.8850 mL 7.2125 mL
20 mM 0.2164 mL 1.0819 mL 2.1638 mL 5.4094 mL
25 mM 0.1731 mL 0.8655 mL 1.7310 mL 4.3275 mL
30 mM 0.1443 mL 0.7213 mL 1.4425 mL 3.6063 mL
40 mM 0.1082 mL 0.5409 mL 1.0819 mL 2.7047 mL
50 mM 0.0866 mL 0.4328 mL 0.8655 mL 2.1638 mL
60 mM 0.0721 mL 0.3606 mL 0.7213 mL 1.8031 mL
80 mM 0.0541 mL 0.2705 mL 0.5409 mL 1.3523 mL
100 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0819 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Guanabenz
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