Guanabenz

Cat. No.: HY-12724: FAQs
Data Sheet Handling Instructions

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Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Guanabenz hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Guanabenz Chemical Structure

CAS No. : 5051-62-7

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Guanabenz:

Guanabenz Acetate

Other Forms of Guanabenz:

2 Publications Citing Use of MCE Guanabenz

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Toxoplasma

In Vitro

Guanabenz (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability^[1].
Guanabenz (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP^[1].
Guanabenz (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Neonatal rat cardiac myocytes (NRCM)
Concentration:	0.5–50 μM
Incubation Time:	24 h
Result:	Did not affect cell survival.

RT-PCR^[1]

Cell Line:	Neonatal rat cardiac myocytes (NRCM)
Concentration:	0.5–50 μM
Incubation Time:	24 h
Result:	Did not affect levels of UPR targets.

Western Blot Analysis^[1]

Cell Line:	Neonatal rat cardiac myocytes (NRCM)
Concentration:	0.5–50 μM
Incubation Time:	24 h
Result:	Increased the levels of low panel concentration-dependent UPR targets proteins.

In Vivo

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden^[2].
Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice^[2].
Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/cJ mice^[2]
Dosage:	5 mg/kg
Administration:	5 mg/kg/day; i.p. ; for 3 weeks
Result:	Reduced the latent brain cysts in both male and female BALB/cJ mice.

Animal Model:	BALB/cJ mice^[2]
Dosage:	5 mg/kg; 10 mg/kg
Administration:	5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks
Result:	Reversed parasite-induced hyperactivity to near-baseline levels.

Animal Model:	Cats^[3]
Dosage:	100 and 320 μg/kg and 1 mg/kg
Administration:	100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
Result:	Declined markedly blood pressure and nerve activity.

Clinical Trial

Molecular Weight

231.08

Formula

C₈H₈Cl₂N₄

CAS No.

5051-62-7

SMILES

ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9(6):e98893. [Content Brief]

[2]. Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10(2):e00381-19. [Content Brief]

[3]. T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37(1):31-44. [Content Brief]

Guanabenz Related Classifications

Cardiovascular Disease

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanabenz5051-62-7Adrenergic ReceptorParasiteBeta Receptorα-2-adrenoceptorantihypertensiveantiparasiticERhigh blood pressureInhibitorinhibitorinhibit

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