2. Protein Tyrosine Kinase/RTK
  3. Tie VEGFR
  4. GW768505A free base

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity。

For research use only. We do not sell to patients.

GW768505A free base Chemical Structure

GW768505A free base Chemical Structure

CAS No. : 501693-25-0

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

GW768505A free base Related Antibodies

Top Publications Citing Use of Products

View All Tie Isoform Specific Products:

View All Isoforms
Tie2

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。

IC50 & Target[1]

KDR

 

Tie2

 

Tie-2

 

In Vitro

GW768505A free base has inhibition for cancer cells growth in NCI-60 panel screening[2].
GW768505A free base is an inhibitor of KDR and TIE2, shows potent inhibition (71–88% inhibition at 100 nM) of the tropomysin-related kinases TRKA, TRKB and TRKC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW768505A free base Related Antibodies
Molecular Weight

537.47

Formula

C27H19F4N5O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C3=C(C4=CC=C(OC)C=C4)OC5=NC=NC(N)=C53)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (15.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8606 mL 9.3028 mL 18.6057 mL
5 mM 0.3721 mL 1.8606 mL 3.7211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8606 mL 9.3028 mL 18.6057 mL 46.5142 mL
5 mM 0.3721 mL 1.8606 mL 3.7211 mL 9.3028 mL
10 mM 0.1861 mL 0.9303 mL 1.8606 mL 4.6514 mL
15 mM 0.1240 mL 0.6202 mL 1.2404 mL 3.1009 mL
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GW768505A free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW768505A501693-25-0TieVEGFRAngiopoietin receptorVascular endothelial growth factor receptorVEGFR2KDRanti-angiogenicInhibitorinhibitorinhibit

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