2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HS-131

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers.

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HS-131 Chemical Structure

HS-131 Chemical Structure

CAS No. : 2084850-40-6

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HS-131 Related Antibodies

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Description

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers[1].
In Vitro

HS-131 Related Antibodies

Immunofluorescence[1]

Cell Line: Tumor cells.
Concentration: 10 µM.
Incubation Time: 30 min.
Result: Tissues/organs, including eyes, brain, heart, lung, liver, spleen, kidney, gut, urinary bladder and skin, were imaged ex vivo by the IVIS imager machine, an imaging modality that detects IR at 640 nm.
In Vivo

HS131 (10 nmol/mouse) could label breast cancers with different molecular subtypes, including MCF-7 and T-47D for luminal type, BT474M1 and KPL-4 for HER2+ subtype, MDA-MB-231 and MDA-MB-468 for triple negative subtype were chosen after considering the tumorigenic capacities of breast cancer cell lines in SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-beige mice bearing human breast cancer xenografts of different molecular subtypes[1].
Dosage: 10 nmol/mouse.
Administration: Injected intravenously.
Result: All breast cancer xenografts with different molecular subtypes showed stronger nIR signals in tumor by intravenous administration of HS131 compared to HS152, and the retention of the nIR signals was detectable even at the 24 h time point in HS131 injected mice.
Molecular Weight

1318.68

Formula

C71H95N7O13S2
CAS No.
Emission (Em)

710
Excitation (Ex)

640
SMILES

CC1=NN(C2=CC(NCCCOCCOCCOCCOCCOCCCNCC3=CC=C(C=C3)C(/C=C/C4=[N+](C5=CC=CC=C5C4(C)C)CCCCS(=O)([O-])=O)=C\C=C6N(C7=CC=CC=C7C\6(C)C)CCCCS(=O)(O)=O)=C(C=C2)C(N)=O)C8=C1C(CC(C)(C8)C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HS-131 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-1312084850-40-6HS131HS 131HSPHeat shock proteinsbreastcancerdyeMCF-7T-47DInhibitorinhibitorinhibit

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