2. Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt NF-κB
  3. MMP COX Interleukin Related p38 MAPK ERK Keap1-Nrf2
  4. Hydrangenol

Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level.

For research use only. We do not sell to patients.

Hydrangenol Chemical Structure

Hydrangenol Chemical Structure

CAS No. : 480-47-7

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Based on 1 publication(s) in Google Scholar

Hydrangenol Related Antibodies

Top Publications Citing Use of Products

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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COX COX-1 COX-2 COX-3

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].

IC50 & Target[1]

MMP-1

 

MMP-3

 

COX-2

 

IL-6

 

In Vivo

Hydrangenol (5-40 mg/kg; p.o.; daily for 7 weeks) mitigated wrinkle formation, dorsal thickness, dehydration, and collagen degradation in UVB-irradiated HR-1 hairless mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UVB-irradiated HR-1 hairless mice[1]
Dosage: 5, 10, 20, or 40 mg/kg
Administration: Oral gavage; daily for 7 weeks
Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation.
Increased the expression of Pro-COL1A1.
Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).
Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).
Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
Molecular Weight

256.25

Formula

C15H12O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(O)C=CC=C2CC(C3=CC=C(O)C=C3)O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Hydrangenol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrangenol480-47-7MMPCOXInterleukin Relatedp38 MAPKERKKeap1-Nrf2Matrix metalloproteinasesCyclooxygenaseILExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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