Isorhamnetin 3,7-di-O-β-D-glucopyranoside (Synonyms: Isorhamnetin-3,7-diglucoside; Isorhamnetin diglucoside)

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Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant.

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Isorhamnetin 3,7-di-O-β-D-glucopyranoside Chemical Structure

CAS No. : 6758-51-6

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Description

Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant^[1].

In Vivo

Isorhamnetin 3,7-di-O-β-D-glucopyranoside (10 or 20 mg/kg of body weight/day for 10 days; p.o.) to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose and 5-(hydroxymethyl)furfural (5-HMF), which is glycosylated with hemoglobin and is an indicator of oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (5 weeks old, 120-130 g) (STZ-induced diabetic rats had higher glucose and 5-HMF levels than normal rats)^[1]
Dosage:	10 or 20 mg/kg of body weight
Administration:	P.o.; daily for 10 days
Result:	The serum glucose levels of rats given 10 and 20 mg of orally were 510.1 and 492.4 mg/dL, respectively, whereas the control level was 574.2 mg/dL.

Molecular Weight

640.54

Formula

C₂₈H₃₂O₁₇

CAS No.

6758-51-6

SMILES

O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=C(C2=CC(OC)=C(C=C2)O)OC3=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C5)C3=C5O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yokozawa T, et al. Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem. 2002;50(19):5490-5495. [Content Brief]

Isorhamnetin 3,7-di-O-β-D-glucopyranoside Related Classifications

Metabolic Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isorhamnetin 3,7-di-O-β-D-glucopyranoside6758-51-6Isorhamnetin-3,7-diglucoside Isorhamnetin diglucosideOthersantioxidantratsdiabetesglucose5-HMFlevelsInhibitorinhibitorinhibit

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