2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Isotetrandrine

Isotetrandrine is a bioactive component in Stephania tetrandra.

For research use only. We do not sell to patients.

Isotetrandrine Chemical Structure

Isotetrandrine Chemical Structure

CAS No. : 477-57-6

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Based on 1 publication(s) in Google Scholar

Isotetrandrine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Isotetrandrine

  • Biological Activity

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  • References

  • Customer Review

Description

Isotetrandrine is a bioactive component in Stephania tetrandra[1].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
A-431 ED50
8.4 μg/mL
Compound: 4
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
HT-1080 ED50
11 μg/mL
Compound: 4
Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
KB ED50
10600 nM
Compound: 18
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
[PMID: 9917283]
KB ED50
6.6 μg/mL
Compound: 4
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
KB-V1 ED50
1.5 μg/mL
Compound: 4
Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
LNCaP ED50
9.4 μg/mL
Compound: 4
Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
P388 ED50
5.6 μg/mL
Compound: 4
Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
[PMID: 8450319]
SK-MEL-2 ED50
19.5 μg/mL
Compound: 4
Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
ZR-75-1 ED50
5 μg/mL
Compound: 4
Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
[PMID: 8450319]
In Vitro

Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum, has been widely used for the treatment of rheumatic arthritis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isotetrandrine Related Antibodies
Molecular Weight

622.75

Formula

C38H42N2O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=C(O2)C3=C(C=C1OC)CCN(C)[C@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C=C5)C[C@@]6([H])C7=C(CCN6C)C=C(OC)C2=C7)=C4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References
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Isotetrandrine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isotetrandrine477-57-6Endogenous MetaboliteInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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