2. Protein Tyrosine Kinase/RTK
  3. Src FAK
  4. JP-153

JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease.

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JP-153 Chemical Structure

JP-153 Chemical Structure

CAS No. : 1802937-26-3

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Description

JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1].

Molecular Weight

365.38

Formula

C21H19NO5
CAS No.
Appearance

Solid

SMILES

O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=C4C=CC=CC4=C3N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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JP-153 Related Classifications

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Keywords:

JP-1531802937-26-3JP153JP 153SrcFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseSrc-FAK-Paxillin signaling inhibitorneovascular eye diseaseVEGFInhibitorinhibitorinhibit

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HY-120417
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